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| | Isoalantolactone Basic information |
| Product Name: | Isoalantolactone | | Synonyms: | 11(13)-dien-12-oicacid,8-beta-hydroxy-eudesma-4(14gamma-lactone;ISOALANTOACTONE;ISOALANTOLACTONE;ISOHELENIN;(3ar,4as,8ar,9ar)-8a-methyl-3,5-dimethylene-decahydro-naphtho[2,3-b]furan-2-one;methyl-3,5-bis(methylene)-,(3aR,4aS,8aR,9aR)-;Naphtho[2,3-b]furan-2(3H)-one,decahydro-8a-;(3aR)-3aα,4,4aα,5,6,7,8,8a,9,9aα-Decahydro-3,5-bismethylene-8aβ-methylnaphtho[2,3-b]furan-2(3H)-one | | CAS: | 470-17-7 | | MF: | C15H20O2 | | MW: | 232.32 | | EINECS: | | | Product Categories: | Inhibitors;Miscellaneous Natural Products;chiral;chemical reagent;pharmaceutical intermediate;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 470-17-7.mol |  |
| | Isoalantolactone Chemical Properties |
| Hazard Codes | Xn | | Risk Statements | 40 | | Safety Statements | 22-36 | | HS Code | 29322090 |
| | Isoalantolactone Usage And Synthesis |
| Description | Isohelenin (470-17-7) is a sesquiterpene lactone isolated from Mexican Indian medicinal plants known to have anti-inflammatory properties. A potent inhibitor of NFkB (complete inhibition at 5 μM)1 acting via inhibition of IKK?6. Isohelenin-mediated NFkB inhibition suppresses IL-8 expression2, iNOS expression3 and RANTES biosynthesis4. Displays protective effects in endotoxic shock in rodent models.5 Induces apoptosis in glioma cells.6 | | Uses | Isoalantolactone is a sesquiterpene lactone used in the treatment of cancer. It can inhibit tumor cell growth and induce apoptosis. | | Definition | ChEBI: A sesquiterpene lactone of the eudesmanolide group. It has been isolated from Inula helenium. | | References | Bork et al. (1997), Sesquiterpene lactone containing Mexican Indian medicinal plants and pure sesquiterpene lactones as potent inhibitors of transcription factor NK-kappaB; FEBS Lett., 402 85
Mazor et al. (2000), Sesquiterpene lactones are potent inhibitors of interleukin 8 gene expression in cultured human respiratory epithelium; Cytokine, 12 239
Wong and Menendez (1999), Sesquiterpene lactones inhibit inducible nitric oxide synthase gene expression in cultured rat aortic smooth muscle cells; Biochem. Biophys. Res. Commun., 262 375
Li et al. (2001), Induction of RANTES chemokine expression in human astrocytic cells is dependent upon activation of NK-kappaB transcription factor; Int. J. Mol. Med., 7 527
Sheehan et al. (2002), Protective effects of isohelenin, an inhibitor of nuclear factor KappaB in endotoxic shock in rats; Endotoxin Res, 8 99
Xing et al. (2019), Isoalantolactone inhibits IKK? kinase activity to interrupt the NF-kB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma; Cancer Med., 8 1655 |
| | Isoalantolactone Preparation Products And Raw materials |
| Raw materials | Naphtho[2,3-b]furan-2(3H)-one, decahydro-3,8a-dimethyl-5-methylene-3-(phenylseleno)-, [3S-(3α,3aβ,4aβ,8aα,9aβ)]- (9CI)-->Naphtho[2,3-b]furan-2(3H)-one, decahydro-8a-methyl-5-methylene-3-[(phenylthio)methylene]-, [3aR-(3E,3aα,4aα,8aβ,9aα)]- (9CI) |
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