LIMAPROST

LIMAPROST Basic information
Product Name:LIMAPROST
Synonyms:(2e,11-alpha,13e,15s,17s)-11,15-dihydroxy-17,20-dimethyl-9-oxoprost-2,13-die;,13e,15s,17s)-;11α,15s-dihydroxy-17s,20-dimethyl-9-oxo-prosta-2e,13e-dien-1-oic acid;17S,20-Dimethyl-trans-D2-PGE1;2-Heptenoic acid, 7-[(1R,2R,3R)-3-hydroxy-2-[(1E,3S,5S)-3-hydroxy-5-methyl-1-nonenyl]-5-oxocyclopentyl]-, (2E)- (9CI);Prosta-2,13-dien-1-oic acid, 11,15-dihydroxy-17,20-dimethyl-9-oxo-, (2E,11a,13E,15S,17S)-;17α,20-dimethyl-δ2-PGE1, 11α,15S-Dihydroxy-17S,20-dimethyl-9-oxo-prosta-2E,13E-dien-1-oic acid;(2E)-7-[(1R)-2β-[(1E,3S,5S)-3-Hydroxy-5-methyl-1-nonenyl]-3α-hydroxy-5-oxocyclopentan-1α-yl]-2-heptenoic acid
CAS:74397-12-9
MF:C22H36O5
MW:380.52
EINECS:
Product Categories:Chiral Reagents;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:74397-12-9.mol
LIMAPROST Structure
LIMAPROST Chemical Properties
Melting point 97-100°
Boiling point 550.6±50.0 °C(Predicted)
density 1.118
storage temp. -20°C
solubility DMF: soluble
form crystalline
pka4.78±0.10(Predicted)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 36/37/39-45
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
RTECS UK8362500
MSDS Information
ProviderLanguage
SigmaAldrich English
LIMAPROST Usage And Synthesis
UsesLimaprost is an analog of Prostaglandin E1 with structural modifications intended to give it a prolonged half-life and greater potency. Limaprost is used as an antianginal.
DefinitionChEBI: Limaprost is a long-chain fatty acid.
Biochem/physiol ActionsLimaprost exhibits cytoprotective, vasodilatory, and antiplatelet activity. Limaprost has the potential to treat lumbar spinal canal stenosis (LSCS) and several ischaemic symptoms of thromboangiitis obliterans (TAO).
LIMAPROST Preparation Products And Raw materials
Raw materialsIsopropyl alcohol-->Trifluoroacetic acid-->4-Dimethylaminopyridine-->Methanesulfonyl chloride-->Methanesulfonic acid-->EC 3.1.1.1
Linagliptin Ruxolitinib phosphate Limaprost a-cyclodextrin clathrate,limaprost alfadex Limaprost-d3 LIMAPROST

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