VIP

VIP Basic information
Discovery Structure Gene, mRNA, and precursor Synthesis and release Receptors Signal transduction pathway Biological functions Clinical implications
Product Name:VIP
Synonyms:VASOACTIVE INTESTINAL PEPTIDE (HUMAN, BOVINE, PORCINE, RAT);VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE);VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, AND RAT;VASOACTIVE INTESTINAL PEPTIDE (HUMAN, PORCINE) (BOVINE, RAT, CANINE);VASOACTIVE INTESTINAL PEPTIDE HUMAN, PORCINE, RAT;VASOACTIVE INTESTINAL PEPTIDE, HUMAN, PORCINE, RAT, OVINE;VASOACTIVE INTESTINAL PEPTIDE, PORCINE;VASOACTIVE INTESTINAL PEPTIDE
CAS:40077-57-4
MF:C147H238N44O42S
MW:3325.8
EINECS:200-001-8
Product Categories:VIP and PACAP receptor;Peptide;40077-57-4
Mol File:40077-57-4.mol
VIP Structure
VIP Chemical Properties
density 1.47±0.1 g/cm3(Predicted)
storage temp. −20°C
solubility 1% acetic acid: soluble 0.1%, clear, colorless
form powder
Water Solubility Soluble to 1 mg/ml in water
InChIKeyHEOYHMUESMJFDC-RIWXPGAOSA-N
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
VIP Usage And Synthesis
DiscoveryVIP is a neuropeptide consisting of 28 aa residues, with wide distribution in the central and peripheral nervous systems. VIP has a broad spectrum of biologic actions, and acts as a neurotransmitter or neuromodulator and also as a hormone. VIP was first discovered as a smooth muscle-relaxant vasodilator peptide in the lung; it was isolated from the porcine intestine in 1970. Its original label as a “candidate gastrointestinal hormone” was soon replaced by its new and apparently true identity as a neuropeptide with neurotransmitter and neuromodulator properties.
StructureVIP possesses two segments of secondary structures: a random coil structure in the N-terminal region between positions 1 and 9, and a long α-helical structure in the C-terminal region stretching from position 10 to its C-terminus. The primary structure of VIP is highly conserved in vertebrates with complete identity among mammals except for the guinea pig and opossum. Mr 3326, pI >11. VIP is soluble in water to 20mg/mL.
structure of Aviptadil
Gene, mRNA, and precursorThe human VIP gene, VIP, location 6q25.2, contains seven exons. Each exon encodes a distinct functional domain of the VIP precursor. The VIP precursor polypeptide (preproVIP) contains several additional biologically active peptides, including peptide histidine isoleucine (PHI, found in nonhuman mammals), peptide histidine methionine (PHM, the human equivalent of PHI), and peptide histidine valine (PHV, a C-terminally extended form of PHI and PHM).
Synthesis and releaseVIP gene expression is stimulated by dibutyryl cAMP and by increased PKC activity induced by tumorpromoting phorbol esters. When acting together, cAMP and phorbol esters synergistically stimulate VIP gene transcription via different sites on the gene.
ReceptorsVIP and PACAP share a wide spectrum of biological activity as well as common receptors belonging to the class II of GPCR. Three VIP or PACAP receptor types, which are derived from different genes, are recognized, namely VPAC1, VPAC2, and PAC1. Two of these receptors, VPAC1 and VPAC2, share a high binding affinity in the nanomolar range for VIP and PACAP. A third receptor type, PAC1, has been characterized for its high affinity for PACAP, but low affinity for VIP.
Signal transduction pathwayBy binding to VIP, VPAC acts on the Gs protein and activates PKA via elevation of AC activity and production of cAMP (cAMP-dependent pathway). PKA either inhibits phosphorylation of the downstream MAP/ERK kinase or promotes phosphorylation of cAMP response element binding protein (CREB), which finally leads to the inhibition of NF-κB. Meanwhile, studies have also identified a pathway that inhibits the nuclear entry of NF-κB through VPAC signaling, which inhibits IκB phosphorylation (cAMP-independent pathway).
Biological functionsVIP is extensively distributed in central and peripheral tissues, where it acts as a neurotransmitter and neuromodulator.8 The main activity of VIP is vasodilatation. VIP induces the dilation of vessels, which results in increased blood flow, decreased peripheral vascular resistance, and hypotension. While VIP has a suppressive effect on the intestinal smooth muscle, it exerts relaxant effects on the lower esophageal sphincter, the sphincter of Oddi, the anal sphincter, and the bronchial smooth muscle. In the small intestine, VIP facilitates the secretion of electrolytes and aqueous liquid. In the stomach, it inhibits gastric secretion. In the pancreas, VIP facilitates the external secretion of bicarbonic acid and aqueous liquid from pancreatic epithelial cells, and facilitates enzyme secretion from acinar cells. VIP promotes the secretion of both insulin and glucagon in a glucose-dependent manner. VIP is broadly distributed in the central nervous system, especially in the hypothalamus and pituitary anterior lobe, and is associated with the regulation of pituitary hormones. VIP is produced by lymphoid tissue and exerts a wide spectrum of immunological functions, controlling the homeostasis of the immune system through different receptors expressed in various immunocompetent cells. VIP acts as a growth factor. It functions as a proliferative factor in normal tissue cells as well as in cancer cells. VIP might inhibit apoptosis by stimulating the expression of the apoptosis-inhibiting gene Bcl2 or by inhibiting the activity of caspase 3.
Clinical implicationsVarious diseases have been reported to involve VIP activity, including bronchial asthma, transmission of pain, cluster headaches, Alzheimer’s disease, Parkinson’s disease, and brain injury.
UsesPulmonary hypertension;Erectile dysfunction
UsesVasoactive Intestinal Peptide human, porcine, rat has been used as an immunogen to analyze the immunohistochemical reactions. It has also been used in cell migration assay.
General DescriptionVasoactive intestinal peptide (VIP) is widely distributed inthe body and is believed to occur throughout the gastrointestinaltract. It is a 28-residue polypeptide with structuralsimilarities to secretin and glucagon. It causes vasodilatationand increases cardiac contractibility. VIP stimulates bicarbonatesecretion, relaxes gastrointestinal and othersmooth muscles, stimulates glycogenesis, inhibits gastricacid secretion, and stimulates insulin secretion. Its hormonaland neurotransmitter role has been investigated.
Biochem/physiol ActionsVIP (Vasoactive intestinal peptide) possesses anti-inflammatory and immunomodulatory functions. It controls the pathogenesis of rheumatoid arthritis. It is also involved in neuroblastoma differentiation, and pancreatic insulin secretion. Vip exhibits its function through G-protein coupled receptors. Some of the other important actions of VIP is associated with the digestive, respiratory, cardiovascular and reproductive systems.
Clinical Use28-peptide that is structurally related to secretin and glucagon. It has a diverse biological actions. It has orphan drug status for the treatment of acute esophageal food impaction.
Clinical UseSeveral clinical trials have been reported regarding the use of VIP or its analog for asthma and sarcoidosis. In an open clinical Phase II study, patients with histologically proven sarcoidosis and active disease were treated with nebulized VIP. VIP inhalation was safe and well tolerated, and significantly reduced the production of tumor necrosis factor-α by cells isolated from the bronchoalveolar lavage fluids of these patients.
storageStore at -20°C
VIP Preparation Products And Raw materials
iodinated vasoactive intestinal peptide (MET(O)17)-VIP,VIP SULFOXIDE (HUMAN, BOVINE, PORCINE, RAT) CAMBO-VIP protocol vasoactive intestinal peptide (6-23) [D-Ala4]VIP vasoactive intestinal peptide (22-28) [Phe1]VIP PACAP/VIP receptor Neurotensin6-11VIP7-28,VIP neurotensin,[Lys1,Pro2,5,Arg3,4,Tyr6]VIP vasoactive intestinal peptide 2 receptor Receptors, Vasoactive Intestinal Peptide [GLP16]-VASOACTIVE INTESTINAL PEPTIDE (16-28), HUMAN, PORCINE, RAT,[GLP16] VASOACTIVE INTESTINAL PEPTIDE (16-28), PORCINE,[GLP16] VIP (16-28), PORCINE vasoactive intestinal peptide (1-12) ANTI-VIP-KLH ANTI-CD71 (HUMAN)-CLONE VIP-1 Vasoactive intestinal peptide from porcine VIP (3-28) (HUMAN, BOVINE, PORCINE, RAT) PREPRO VASOACTIVE INTESTINAL PEPTIDE (156-170),PREPRO VASOACTIVE INTESTINAL PEPTIDE/PHM (156-170) (HUMAN)

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