Methyl 2-acetamidoacrylate

Methyl 2-acetamidoacrylate Basic information

Product Name:	Methyl 2-acetamidoacrylate
Synonyms:	2-ACETAMIDOACRYLIC ACID METHYL ESTER;METHYL 2-ACETAMIDOACRYLATE;Ac-DL-Dha-OMe~2-Acetamidoacrylic acid methyl ester~N-Acetyldehydroalanine methyl ester;ac-dl-dha-ome;2-Acetylaminoacrylic acid methyl ester;Methyl 2-(acetylamino)propenoate;N-Acetyl-2,3-didehydroalanine methyl ester;N-Acetyl-2-methyleneglycine methyl ester
CAS:	35356-70-8
MF:	C6H9NO3
MW:	143.14
EINECS:
Product Categories:	AcrylateCarbonyl Compounds;Acrylic Monomers;C6 to C7;Esters;Monomers
Mol File:	35356-70-8.mol

Methyl 2-acetamidoacrylate Chemical Properties

Melting point	50-52 °C (lit.)
Boiling point	104 °C/8 mmHg (lit.)
density	1.3075 (rough estimate)
refractive index	1.4340 (estimate)
Fp	>230 °F
storage temp.	under inert gas (nitrogen or Argon) at 2-8°C
solubility	Chloroform (Slightly), Methanol (Slightly)
form	Solid
pka	13.12±0.46(Predicted)
color	Off-White
BRN	1812208
CAS DataBase Reference	35356-70-8(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	26-37/39
WGK Germany	3
HS Code	29241990

MSDS Information

Provider	Language
SigmaAldrich	English
ALFA	English

Methyl 2-acetamidoacrylate Usage And Synthesis

Uses

Methyl 2-acetamidoacrylate exhibits anti-inflammatory property and decreases induced acute kidney injury in mice.

General Description

Conjugated addition of secondary amines, imidazole and pyrazole to methyl 2 methyl 2-acetamidoacrylate in the presence of a catalyst results in the formation of β-Dialkylamino-α-alanine and β-(N-heteroaryl)-α-alanine derivatives. Methyl-2-acetamidoacrylate (M2AA) is an anti-inflammatory agent. The catalytic reaction of methyl 2-acetamidoacrylate with Grignard′s reagents affords α-amino esters. M2AA can form thermosensitive copolymers with methyl acrylate.

Methyl 2-acetamidoacrylate Preparation Products And Raw materials

Raw materials	Propanoic acid, 2-azido-, methyl ester-->2-(Hydroxyimino)propanoic acid methyl ester-->N-ACETYL-L-CYSTEINE METHYL ESTER-->2-Acetamidoacrylic acid-->Methyl 2-acetylamino-3-chloropropionate-->Iodomethane-->Methyl pyruvate-->Acetamide-->Acetic anhydride
Preparation Products	2-ACETAMIDOPROPIONIC ACID METHYL ESTER-->2-Pyridinecarboxylic acid, 6-chloro-5-forMyl-, Methyl ester-->Methyl 3-isoquinolinecarboxylate

N-(5-BENZOYL-6-METHYL-2-OXO-2H-PYRAN-3-YL)-4-CHLOROBENZENECARBOXAMIDE METHYL 3-[(4-CHLOROBENZOYL)AMINO]-6-METHYL-2-OXO-2H-PYRAN-5-CARBOXYLATE METHYL 3-(BENZOYLAMINO)-6-METHYL-2-OXO-2H-PYRAN-5-CARBOXYLATE 3-MALEIMIDO-4-METHYL-6,7-METHYLENEDIOXYCOUMARIN ETHYL 3-[(4-CHLOROBENZOYL)AMINO]-2-OXO-6-PHENYL-2H-PYRAN-5-CARBOXYLATE N-(2,5-DIOXO-5,6,7,8-TETRAHYDRO-2H-CHROMEN-3-YL)-4-METHOXYBENZENECARBOXAMIDE 3-ACETAMIDOCOUMARIN N-(5-BENZOYL-6-METHYL-2-OXO-2H-PYRAN-3-YL)-4-METHOXYBENZENECARBOXAMIDE N-(5-ACETYL-6-METHYL-2-OXO-2H-PYRAN-3-YL)BENZENECARBOXAMIDE N-(2,5-DIOXO-5,6,7,8-TETRAHYDRO-2H-CHROMEN-3-YL)BENZENECARBOXAMIDE DACM 4-CHLORO-N-(2,5-DIOXO-5,6,7,8-TETRAHYDRO-2H-CHROMEN-3-YL)BENZENECARBOXAMIDE N-(5-ACETYL-6-METHYL-2-OXO-2H-PYRAN-3-YL)-4-METHOXYBENZENECARBOXAMIDE N-(5-BENZOYL-6-METHYL-2-OXO-2H-PYRAN-3-YL)BENZENECARBOXAMIDE N-(5-ACETYL-6-METHYL-2-OXO-2H-PYRAN-3-YL)-4-CHLOROBENZENECARBOXAMIDE ETHYL 3-(BENZOYLAMINO)-2-OXO-6-PHENYL-2H-PYRAN-5-CARBOXYLATE Methyl 2-acetamidoacrylate ETHYL 3-[(4-METHOXYBENZOYL)AMINO]-2-OXO-6-PHENYL-2H-PYRAN-5-CARBOXYLATE

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Methyl 2-acetamidoacrylate

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