| Uses | Antiparkinsonian (D2receptor agonist). |
| Definition | ChEBI: Ropinirole is a member of indolones and a tertiary amine. It has a role as a dopamine agonist, an antiparkinson drug, a central nervous system drug and an antidyskinesia agent. |
| Brand name | Requip (GlaxoSmithKline). |
| Synthesis Reference(s) | Journal of Medicinal Chemistry, 28, p. 1533, 1985 DOI: 10.1021/jm00148a028 |
| Clinical Use |
Anti-Parkinson agent
Restless legs syndrome (RLS) |
| Drug interactions | Potentially hazardous interactions with other drugs
Antipsychotics: antagonism of anti-Parkinsonian
effect - avoid.
Metoclopramide: antagonism of anti-Parkinsonian
effect - avoid.
Oestrogens: concentration increased. |
| Metabolism | Ropinirole is hepatically metabolised by the cytochrome
P450 enzyme, CYP1A2, and excreted in the urine as
inactive metabolites. |
