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CAPTOPRIL DISULFIDE

CAPTOPRIL DISULFIDE Basic information
Product Name:CAPTOPRIL DISULFIDE
Synonyms:CAPTOPRIL DISULFIDE;CAPTOPRIL DISULFIDE USP;CAPTOPRIL DISULFIDE USP(CRM STANDARD);CAPTOPRIL DISULFIDE WHO(CRM STANDARD);CAPTOPRIL DISULPHIDE BP STANDARD;Captopril ImpurityⅠ:Captopril Disulfide{ 1,1'-[Dithiobis[(2S)-2-methyl-1-oxo-3,1-propanediyl]]bis-L-proline CAPTOPRDS};Imp. A (EP):1,1'-[Disulfanediylbis-[(2S)-2-methyl-1-oxopropane-3,1-diyl]]-bis[(2S)-pyrrolidine-2-carboxylic] Acid(Captopril Disulfide);Captopril Impurity A
CAS:64806-05-9
MF:C18H28N2O6S2
MW:432.55
EINECS:
Product Categories:Intermediates & Fine Chemicals;Metabolites & Impurities;Pharmaceuticals
Mol File:64806-05-9.mol
CAPTOPRIL DISULFIDE Structure
CAPTOPRIL DISULFIDE Chemical Properties
Melting point 224-226°C
Boiling point 714.8±60.0 °C(Predicted)
density 1.383±0.06 g/cm3(Predicted)
storage temp. -20°C Freezer
solubility DMSO (Slightly), Ethanol (Slightly, Sonicated), Methanol (Slightly, Sonicated)
form neat
pka3.29±0.20(Predicted)
color White to Off-White
Safety Information
WGK Germany 3
HS Code 2933999552
MSDS Information
CAPTOPRIL DISULFIDE Usage And Synthesis
DescriptionCaptopril disulfide is a metabolite and symmetrical disulfide form of the angiotensin converting enzyme (ACE) inhibitor captopril . Captopril disulfide is the main degradation product of captopril and is formed by oxidation. It is a potential impurity in commercial preparations of captopril. Captopril disulfide inhibits angiotensin I-induced increases in mean arterial pressure in anesthetized dogs (ID50 = 0.231 mg/kg, i.v.).
Chemical PropertiesWhite Solid
UsesCaptopril Disulfide (Captopril EP Impurity A) is a metabolite of Captopril. A new antihypertensive agent.
DefinitionChEBI: An organic disulfide in which the disulfide bond links two units of captopril. It is a secondary metabolite of captopril.
CAPTOPRIL DISULFIDE Preparation Products And Raw materials
5'-Deoxy-5-fluorocytidine 2'-O-(5'-Deoxy-β-D-ribofuranosyl) Capecitabine pentyl(1-((2R,3R,4R,5R)-3,4-bis(((2S,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)oxy)-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydropyrimidin-4-yl)carbamate (2S)-1-[(2S)-2-Methyl-3-Methylsulfinylpropanoyl]pyrrolidine-2-carboxylic acid 1-[(2S)-3-BroMo-2-Methyl-1-oxopropyl]-L-proline Ion pair reagent CAPECITABINE related substance USP 1-[(2R)-3-Hydroxy-2-Methyl-1-oxopropyl]-L-proline 5'-Deoxy-5-fluoro-N-[(2-methylbutoxy)carbonyl]cytidine Captopril Captopril tablets alpha-Capecitabine Canagliflozin Dimer (2S)-1-[2-Methylpropanoyl]-pyrrolidine-2-carboxylic Acid CAPTOPRIL IMP. A (EP): CAPTOPRIL DISULPHIDE MM DIISOBUTYL DISULFIDE CAPTOPRIL DISULFIDE WHO CAPTOPRIL DISULFIDE
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