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| | Indinavir sulfate Basic information |
| | Indinavir sulfate Chemical Properties |
| Melting point | 150-153°C (dec) | | storage temp. | -20°C Freezer | | solubility | Freely soluble in water, soluble in methanol, practically insoluble in heptane. | | form | Solid | | color | White to Off-White | | Water Solubility | >100g/L(temperature not stated) | | BCS Class | 2,4 |
| | Indinavir sulfate Usage And Synthesis |
| Description | Indinavir is an HIV-1 protease inhibitor (Ki = 0.358 nM). It is selective for HIV-1 protease over HIV-2 protease (Ki = 3.316 nM), as well as human cathepsin D, porcine pepsin, bovine chymosin, human plasma renin, Factor Xa, and elastase at 10 μM. It is also selective for wild-type HIV-1 protease over the protease inhibitor-resistant mutants A-44, K-60, and V-18 (Kis = 0.24, 15, 50, and 40 nM, respectively). Indinavir is active against multiple HIV-1 variants in cell-based assays (IC95s = 12-100 nM). Formulations containing indinavir have been used in combination with antiretroviral agents in the treatment of HIV infection. | | Chemical Properties | Crystalline Solid | | Uses | Indinavir Sulfate is a member of the novel hydroxyaminopentane amide class of HIV-1 protease inhibitors. Antiviral. It is a COVID19-related research product. | | Definition | ChEBI: Indinavir sulfate is an azaheterocycle sulfate salt. It is functionally related to an indinavir. | | Brand name | Crixivan (Merck). | | Hazard | Moderately toxic by ingestion. | | storage | RT |
| | Indinavir sulfate Preparation Products And Raw materials |
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