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| | 2,6-Dichlorobenzoyl chloride Basic information |
| Product Name: | 2,6-Dichlorobenzoyl chloride | | Synonyms: | Benzoyl chloride, 2,6-dichloro-;DICHLOROBENZOYLCHLORIDE(2,6-);2,6-DICHLOROBENZOYL CHLORIDE;2,6-DICHLORBENZOYL CHLORIDE;2,6-DICHLOROBENZOYL CHLORIDE 98+%;Benzoyl chloride, 2,6-dichloro- (6CI,7CI,8CI,9CI);2,6-Dichlorobenzoyl;2,6-Dichlorobenzoic acid chloride | | CAS: | 4659-45-4 | | MF: | C7H3Cl3O | | MW: | 209.46 | | EINECS: | 225-102-4 | | Product Categories: | Acid Halides;Carbonyl Compounds;ACIDHALIDE;Organic Building Blocks | | Mol File: | 4659-45-4.mol |  |
| | 2,6-Dichlorobenzoyl chloride Chemical Properties |
| Melting point | 15-17 °C | | Boiling point | 142-143 °C/21 mmHg (lit.) | | density | 1.462 g/mL at 25 °C (lit.) | | refractive index | n20/D 1.560(lit.) | | Fp | >230 °F | | storage temp. | Inert atmosphere,2-8°C | | form | Liquid | | color | Clear colorless to light yellow or light pink | | Water Solubility | Miscible with alcohol, ether and acetone. Slightly miscible with heptane. Immiscible with water. | | Sensitive | Moisture Sensitive | | BRN | 639531 | | CAS DataBase Reference | 4659-45-4(CAS DataBase Reference) | | NIST Chemistry Reference | 2,6-Dichlorobenzoyl chloride(4659-45-4) |
| Hazard Codes | C | | Risk Statements | 34 | | Safety Statements | 26-27-36/37/39-45 | | RIDADR | UN 3265 8/PG 2 | | WGK Germany | 1 | | F | 10-19-21 | | HazardClass | 8 | | PackingGroup | II | | HS Code | 29163900 |
| | 2,6-Dichlorobenzoyl chloride Usage And Synthesis |
| Chemical Properties | Clear slightly yellow liquid | | Uses | 2,6-Dichlorobenzoyl chloride acts as an important intermediate in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs. It is employed in the substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases. It is also used in the preparation of 1-acyliridoles and (-)-aspicilin. In addition to this, it undergoes esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene. | | Uses | 2,6-Dichlorobenzoyl chloride was used:
- in substrate activity screening method for the rapid development of novel substrates and their conversion into non-peptidic inhibitors of Cys and Ser proteases
- in the synthesis of 1-acyliridoles
- in enantiocontrolled total synthesis of (-)-aspicilin
| | General Description | 2,6-Dichlorobenzoyl chloride participates in esterification of (fluoren-9-ylmethoxy)carbonyl (Fmoc)-amino acids to 4-alkoxybenzyl alcohol polystyrene. | | Purification Methods | Reflux the acid chloride for 2hours with excess of acetyl chloride (3 volumes), distil off AcCl followed by the benzoyl chloride. Store it away from moisture. It is an IRRITANT.[Beilstein 9 III 1377.] |
| | 2,6-Dichlorobenzoyl chloride Preparation Products And Raw materials |
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