ectylurea

ectylurea Basic information

Product Name:	ectylurea
Synonyms:	ectylurea;2-Ethylcrotonylurea;(Z)-N-(Aminocarbonyl)-2-ethyl-2-butenamide;Levanil;(.alpha.-Ethyl-cis-crotonyl)carbamide;(2-Ethyl-cis-crotonyl)urea;2-Butenamide, N-(aminocarbonyl)-2-ethyl-, (Z)-;2-Ethyl-cis-crotonylurea
CAS:	95-04-5
MF:	C7H12N2O2
MW:	156.18
EINECS:	2023868
Product Categories:
Mol File:	95-04-5.mol

ectylurea Chemical Properties

Melting point	198°, also reported as mp 191-193° (lower melting form, mp 158°)
Boiling point	280.42°C (rough estimate)
density	1.1832 (rough estimate)
refractive index	1.4880 (estimate)
pka	11.63±0.46(Predicted)

Safety Information

Toxicity

LD50 in rats (mg/kg): 2500 orally; 900 i.p. (Pindell)

MSDS Information

ectylurea Usage And Synthesis

Originator	Nostyn,Ames,US,1956
Definition	ChEBI: Ectylurea is a N-acylurea.
Manufacturing Process	54 g of carbromal (2-bromo-2-ethylbutyryl-urea) in 600 cc of isopropanol was stirred and refluxed for 3 hours with 27.8 g of anhydrous silver oxide. The reaction mixture was filtered and the silver residue was extracted with 100 cc of boiling isopropanol. The filtered and dried solids which separated weighed 22.5 g and melted at 189°C to 190.5°C. Concentration of the filtrate yielded an additional 3.3 g of product which melted at 160°C to 170°C. These two crops were separately obtained as white needles by crystallization from alcohol and exhibited slight solubility in water. The first crop gave 21.7 g of 2- ethyl-cis-crotonyl urea with a melting point of 191°C to 193°C, and the second crop gave 0.9 g with a melting point of 191°C to 193°C for a total yield of 42.4 g or 63% of the theoretical.
Therapeutic Function	Sedative

ectylurea Preparation Products And Raw materials

Raw materials	Silver oxide
Preparation Products	2-Ethyl-N-[[(hydroxymethyl)amino]carbonyl]-2-butenamide

Ectoine 3-Ethyl-2,5-Dihydro-4-Methyl-2-Oxo-N-(2-Phenylethyl)-1h-Pyrrole-1-Carboxamide Homeostan 4-[2-[(3-Ethyl-4-methyl-2-oxo-3-pyrrolin-1-yl)carboxamido]ethyl]benzenesulfonamide rac trans-Hydroxy Glimepiride-D5 [[4-[2-[[(3-Ethyl-2,5-dihydro-4-methyl-2-oxo-1H-pyrrol-1-yl)carbonyl]amino]ethyl]phenyl]sulfonyl]-carbamic acid ethyl ester Glimepiride ectylurea

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