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| | Brodimoprim Basic information |
| | Brodimoprim Chemical Properties |
| Melting point | 225-228° | | storage temp. | Amber Vial, -20°C Freezer, Under inert atmosphere | | solubility | DMSO (Slightly), Methanol (Sparingly) | | pka | 7.15(at 25℃) | | form | Solid | | color | White to Pale Yellow | | Stability: | Light Sensitive |
| | Brodimoprim Usage And Synthesis |
| Description | Brodimoprim, a dihydrofolate reductase inhibitor, was introduced for the treatment of
common infections of upper respiratory tract such as sinusitis and exacerbation of chronic
bronchitis. It has a broad spectrum of antimicrobial activities against most Gram-positive and
-negative pathogens including some bacterial strains that are resistant to amoxicillin, a widely
used antibiotic for the indicated infections. Brodimoprim also has a favorable pharmacokinetic
profile exemplified by its long half-life and good tissue penetration. | | Chemical Properties | Off-White to Pale Yellow Solid | | Originator | Helsinn (Switzerland) | | Uses | A structural derivative of Trimethoprim (T795615). A selective dihydrofolate reductase inhibitor; diaminopyridine antibacterial agent. | | Definition | ChEBI: An aminopyrimidine that is 2,4-diaminopyrimidine in which the hydrogen at position 5 has been replaced by a 4-bromo-3,5-dimethoxybenzyl group. | | Brand name | Hyprim;Unitrim |
| | Brodimoprim Preparation Products And Raw materials |
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