|
| | Coenzyme A Basic information |
| Product Name: | Coenzyme A | | Synonyms: | [(2R,3R,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-2-[[hydroxy-[hydroxy-[3-hydroxy-2,2-dimethyl-3-[2-(2-sulfanylethylcarbamoyl)ethylcarbamoyl]propoxy]phosphoryl]oxy-phosphoryl]oxymethyl]oxolan-3-yl]oxyphosphonic acid;CONENZYME A;Coenzyme a, free acid;Coenzyme A, free acid, lyophilized, min. 75% (enzym.);COENZYME A FREE ACID FROM YEAST;Coenzyme A, free acid, lyophilized, 75%;Coenzyme A / Q0 / Q10;COENZYM A FREE ACID | | CAS: | 85-61-0 | | MF: | C21H36N7O16P3S | | MW: | 767.53 | | EINECS: | 201-619-0 | | Product Categories: | Vitamin series;85-61-0 | | Mol File: | 85-61-0.mol |  |
| | Coenzyme A Chemical Properties |
| density | 1.96±0.1 g/cm3(Predicted) | | storage temp. | Keep in dark place,Inert atmosphere,Store in freezer, under -20°C | | solubility | PBS (pH 7.2): 10 mg/ml | | form | A crystalline solid | | pka | 9.6 (thiol); pK 6.4 (secondary phosphate); pK 4.0 (adenine NH3+) | | Merck | 13,2491 | | BRN | 77809 | | LogP | -4.358 (est) | | EPA Substance Registry System | Coenzyme A (85-61-0) |
| Safety Statements | 24/25 | | WGK Germany | 3 | | F | 1-10 | | TSCA | Yes | | HS Code | 2933299090 |
| | Coenzyme A Usage And Synthesis |
| Description | Coenzyme A (CoA) is an essential cofactor functioning as an acyl group carrier and carbonyl-activating group for the citric acid cycle and fatty acid metabolism. About 4% of cellular enzymes utilize CoA as a substrate. It is synthesized from pantothenic acid in a 5-step process that requires ATP. The pantothenate kinase step of the CoA biosynthetic pathway has been identified as a target for the development of antibacterial compounds. | | Chemical Properties | yellowish lyophilisate | | Uses | A hydrated form of Coenzyme A (CoA) is a useful biochemical research chemical, used in the preparation of high-yielding cell-free protein synthesis platforms. | | Uses | Coenzyme A hydrate has been used in the thiolase enzyme assay of recombinant acetoacetyl-CoA thiolase (rACAT) in Clonorchis sinensis. It may be used as a reference standard in Raman spectra measurements. | | Definition | ChEBI: Tetraanion of coenzyme A. | | General Description | Coenzyme A is structurally composed of 2-aminoethanethiol, pantothenic acid and phosphorylated adenosine phosphate. | | Biochem/physiol Actions | Coenzyme A is a cofactor involved in acyl group transfer. It is essential for carbohydrate, lipid and protein metabolism. Coenzyme A acts as a cofactor for vitamin B coenzymes. | | Purification Methods | The white powder is best stored in an inert atmosphere in the dark in sealed ampoules after drying in vacuo over P2O5 at 34o. It has UV: max 259 nm ( 16,800) in H2O. [Buyske et al. J Am Chem Soc 76 3575 1954.] It is soluble in H2O but insoluble in EtOH, Et2O and M2CO. It is readily oxidised in air and is best kept as the more stable trilithium salt [Moffat & Khorana J Am Chem Soc 83 663 1961; see also Beinert et al. J Biol Chem 200 384 1953, De Vries et al. J Am Chem Soc 72 4838 1950, Gregory et al. J Am Chem Soc 74 854 1952 and Baddiley Adv Enzymol 16 1 1955]. [Beilstein 26 III/IV 3663.] |
| | Coenzyme A Preparation Products And Raw materials |
|
