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| | (R)-(-)-2-Aminobutane Basic information |
| | (R)-(-)-2-Aminobutane Chemical Properties |
| Melting point | -105°C | | alpha | -7.5 º (c=neat 19 ºC) | | Boiling point | 63 °C(lit.) | | density | 0.72 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.393(lit.) | | Fp | -19°C | | storage temp. | Flammables area | | pka | 10.74±0.10(Predicted) | | form | clear liquid | | color | Colorless to Almost colorless | | optical activity | [α]19/D 7.5°, neat | | Water Solubility | > 10 mg/L | | Sensitive | Air Sensitive | | Merck | 14,1544 | | BRN | 1718760 | | CAS DataBase Reference | 13250-12-9(CAS DataBase Reference) |
| | (R)-(-)-2-Aminobutane Usage And Synthesis |
| Chemical Properties | Colorless to light yellow liqui | | Uses | (R)-(-)-2-Aminobutane is a chiral amine plays an important role in pharmaceutical chemistry and in organic synthesis as chiral auxiliary, which is used to determine the enantiomeric excess (ee). | | Uses | (R)-(?)-sec-Butylamine can be used:
- To prepare (R)-(?)-sec-butylbis(2-hydroxyethyl)amine, an intermediate for the synthesis of aminodiphosphine ligands.
- As a substrate to demonstrate the stereochemistry of Mitsunobu reaction in the synthesis of secondary amines.
- As a model compound in the study of singlet-triplet transitions in circular dichroism.
| | Purification Methods | Dry it over solid NaOH overnight and fractionate it through a short helices packed column. The L-hydrogen tartrate salt has m 139-140o (from H2O), the 1H2O has m 96o []D +18.1o (c 11, H2O), the hydrochloride has m 152o [ ] 21 -1.1o (c 13, H2O) and the benzoyl derivative crystallises from EtOH as needles with m 97o, [] 21 -34.9o (c 11, H2O). [Bruck et al. J Chem Soc 921 1956,Kjaer & Hansen Acta Chem Scand 11 898 1957.] [Beilstein 4 H 161, 4 I 372, 4 III 308, 4 IV 617.] The S -(+)-enantiomer has has same properties except for the optical rotation which has the opposite sign. |
| | (R)-(-)-2-Aminobutane Preparation Products And Raw materials |
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