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Sulfamonomethoxine

Sulfamonomethoxine Basic information
Product Name:Sulfamonomethoxine
Synonyms:4-azanyl-N-(6-methoxypyrimidin-4-yl)benzenesulfonamide;Sulfamonomethoxine,4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide;4-Methoxy-6-sulfanilaMidopyriMidine;4-SulfanilaMido-6-MethoxypyriMidine;6-Methoxy-4-sulfanilaMidopyriMidine;4-Amino-N-(6-methoxy-4-pyrimidinyl)benzenesulfonamide N-(6-Methoxy-4-pyrimidinyl)sulfanilamide;ici32525;n(sup1)-(6-methoxy-4-pyrimidinyl)-sulfanilamid
CAS:1220-83-3
MF:C11H12N4O3S
MW:280.3
EINECS:624-483-8
Product Categories:Heterocycles;Sulfur & Selenium Compounds;Heterocyclic Compounds;Amines;Aromatics;PROSULFA;Inhibitor;1220-83-3
Mol File:1220-83-3.mol
Sulfamonomethoxine Structure
Sulfamonomethoxine Chemical Properties
Melting point 203-2060C
Boiling point 513℃
density 1.3936 (rough estimate)
refractive index 1.6200 (estimate)
Fp >110°(230°F)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility methanol: soluble10mg/mL
pkapKa 5.94 (Uncertain)
form powder
color white to white with yellow cast
Water Solubility Soluble in water at 10mg/ml with warming. Also soluble in ethanol or methanol
BRN 621128
InChIInChI=1S/C11H12N4O3S/c1-18-11-6-10(13-7-14-11)15-19(16,17)9-4-2-8(12)3-5-9/h2-7H,12H2,1H3,(H,13,14,15)
InChIKeyWMPXPUYPYQKQCX-UHFFFAOYSA-N
SMILESC1(S(NC2C=C(OC)N=CN=2)(=O)=O)=CC=C(N)C=C1
CAS DataBase Reference1220-83-3(CAS DataBase Reference)
EPA Substance Registry SystemSulfamonomethoxine (1220-83-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-43
Safety Statements 26-36
WGK Germany 2
RTECS WP0550000
HazardClass IRRITANT
HS Code 29350090
ToxicityLD50 oral in rabbit: > 10gm/kg
MSDS Information
ProviderLanguage
SigmaAldrich English
Sulfamonomethoxine Usage And Synthesis
Chemical PropertiesWhite To Off-White Crystalline Powder
Usesantibacterial
UsesProtein binding. Inhibitor of enzyme. Sulfamonomethoxine and Trimethoprim are used for treating porcine unknown hyperpyrexia.
DefinitionChEBI: Sulfamonomethoxine is a sulfonamide and a member of benzenes.
Synthesis Reference(s)The Journal of Organic Chemistry, 26, p. 2764, 1961 DOI: 10.1021/jo01066a034
General DescriptionChemical structure: sulfonamide
Biochem/physiol ActionsSulfamonomethoxine is a competitive inhibitor of dihydropteroate synthetase used to block the synthesis of folic acid.
Sulfadimethoxine sodium salt Sulfanilamide Sulfadimethoxine Sulfasalazine Vinyltrimethoxysilane Sulfanilic acid Sulfameter Sulfadiazine ALTRENOGEST 4-Aminobenzoic acid 6-Aminocaproic acid Glycine Aniline Sulfamethazine Tris(hydroxymethyl)aminomethane AMINO ACIDS Sulfamonomethoxine Anthranilic acid
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