Vanadinocene Dichloride

Vanadinocene Dichloride Basic information
Product Name:Vanadinocene Dichloride
Synonyms:dichlorodi-pi-cyclopentadienyl-vanadiu;Bis(cyclopentadienyl)vanadium dichloride (Vanadocene dichloride),98%;Dicyclopentadienevanadium dichloride;Dicyclopentadienyldichlorovanadium;Bis(cyclopentadienyl)vanadiuM dichloride, 95% 1GR;Dichlorobis(cyclopentadienyl)vanadium;Bis(cyclopentadienyl)vanadium(IV) dichloride 95%;Bis(cyclopentadienyl)vanadium dichloride, 98% (Vanadocene dichloride)
CAS:12083-48-6
MF:C10H10Cl2V10*
MW:252.03
EINECS:235-150-8
Product Categories:metallocene;Transition Metal Compounds;V (Vanadium) Compounds;Catalysis and Inorganic Chemistry;Chemical Synthesis;Vanadium;Classes of Metal Compounds;Metallocenes;Titanocene, etc.
Mol File:12083-48-6.mol
Vanadinocene Dichloride Structure
Vanadinocene Dichloride Chemical Properties
Melting point 182-194 °C (dec.)(lit.)
density 1,6 g/cm3
storage temp. 2-8°C
form crystal
color green
Specific Gravity1.6
Water Solubility Reacts with water
Sensitive Air & Moisture Sensitive
Exposure limitsNIOSH: Ceiling 0.05 mg/m3
CAS DataBase Reference12083-48-6(CAS DataBase Reference)
EPA Substance Registry SystemVanadocene dichloride (12083-48-6)
Safety Information
Hazard Codes T
Risk Statements 25-36/37/38
Safety Statements 26-28-36/37/39-45
RIDADR UN 3285 6.1/PG 3
WGK Germany 3
RTECS YW1580000
HazardClass 8
PackingGroup II
HS Code 29310099
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
Vanadinocene Dichloride Usage And Synthesis
Chemical Propertiesdark green crystalline powder
UsesVanadocene dichloride is used like other metallocenes as a catalyst, ultraviolet absorber, reducing agent, free radical scavenger, antiknock agent in gasoline, and as a developmental anticancer drug.
UsesBis(cyclopentadienyl)vanadium(IV) dichloride is a catalyst for solvent free, room temperature preparation of vicinal amino alcohols as fungistatic agents, catalyst fot oligomerization reactions via the Aufbau propagation reaction and as a catalyst for aqueous polymerization reactions using oxygen as a co catalyst. It is used as a catalyst for dl-selective pinacol-type coupling reactions, as an affecter of crystal growth of calcium carbonate and and as an inhibitor of human topoisomerase II enzyme with antitumor activity.
General DescriptionPale green crystals or green powder.
Air & Water ReactionsExtremely sensitive to exposure to air. Also extremely sensitive to moisture; decomposes in water
Reactivity ProfileOrganometallics, such as BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE, are reactive with many other groups. Incompatible with acids and bases. Organometallics are good reducing agents and therefore incompatible with oxidizing agents. Often reactive with water to generate toxic or flammable gases. Organometallics containing halogens (fluorine, chlorine, bromine, iodine) bonded to the metal typically with generate gaseous hydrohalic acids (HF, HCl, HBr, HI) with water.
Fire HazardFlash point data for BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE are not available. BIS(CYCLOPENTADIENYL)VANADIUM DICHLORIDE is probably combustible.
Pharmaceutical ApplicationsVanadocene dichloride [( η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic .
Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing. The main problems are the difficult characterisation of the active vanadium compounds and their fast hydrolysis.
Pharmaceutical ApplicationsVanadocene dichloride [(η5-C5H5)2VCl2, dichloro bis(η5-cyclopentadienyl)vanadium(IV)] is structurally very similar to Cp2TiCl2. It also consists of a metal centre with an oxidation number of +IV, in this case vanadium, and two Cp and two chloride ligands. Vanadocene dichloride is a 17-electron complex containing an unpaired electron and is therefore paramagnetic. Vanadocene dichloride has found application as a catalyst for polymerisation reactions, but was also intensively studied as an anticancer agent in parallel to Cp2TiCl2 because of their structural similarities. Vanadocene dichloride has proven to be even more effective than its titanium analogue as an antiproliferative agent against both animal and human cell lines in preclinical testing.
Vanadinocene Dichloride Preparation Products And Raw materials
Raw materialsTRIPHENYLGERMANE-->TRIPHENYLGERMANIUM CHLORIDE
VANADIUM(III) ACETYLACETONATE Dichlorodihydrosilane VIDARABINE (200 MG)G-2939UG/MG(AI) VANADIUM(III) CHLORIDE VANADIUM(II) CHLORIDE BIS(CYCLOPENTADIENYL)VANADIUM Vanadium(V) oxide Vanadinocene Dichloride VANADIUM HYDRIDE 1,3-Cyclopentadiene

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