ETHYL 4-NITROBENZOYLACETATE

ETHYL 4-NITROBENZOYLACETATE Basic information
Product Name:ETHYL 4-NITROBENZOYLACETATE
Synonyms:Acetic acid, (p-nitrobenzoyl)-, ethyl ester;3-keto-3-(4-nitrophenyl)propionic acid ethyl ester;3-Oxo-3-(p-nitrophenyl)propionic acid, ethyl e;4-Nitro-b-oxo-benzenepropanoic acid ethyl ester;Ethyl 3-oxo-3-(4-nitrophenyl)propanoate;NSC 62134;Benzenepropanoic acid, 4-nitro-β-oxo-, ethyl ester;ETHYL 4-NITROBENZOYLACETAT
CAS:838-57-3
MF:C11H11NO5
MW:237.21
EINECS:212-656-7
Product Categories:Aromatic Esters;Benzoic acid;C10 to C11;Carbonyl Compounds;Esters
Mol File:838-57-3.mol
ETHYL 4-NITROBENZOYLACETATE Structure
ETHYL 4-NITROBENZOYLACETATE Chemical Properties
Melting point 67-71 °C
Boiling point 379.74°C (rough estimate)
density 1.3350 (rough estimate)
refractive index 1.5300 (estimate)
storage temp. Sealed in dry,Room Temperature
pka8.70±0.25(Predicted)
form powder to crystal
color White to Light yellow to Light orange
BRN 1124763
CAS DataBase Reference838-57-3(CAS DataBase Reference)
EPA Substance Registry SystemBenzenepropanoic acid, 4-nitro-.beta.-oxo-, ethyl ester (838-57-3)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 24/25-36/37-26
WGK Germany 2
RTECS AJ1073500
TSCA Yes
HazardClass IRRITANT
HS Code 29183000
MSDS Information
ProviderLanguage
ACROS English
ALFA English
ETHYL 4-NITROBENZOYLACETATE Usage And Synthesis
Chemical Propertiesyellow fine crystalline powder
UsesIt is employed as a reactant involved in synthesis of β-1,3-dicarbonyl aldehydes via oxidation, knoevenagel condensation using a lysine catalyst, and cycloisomerization for the synthesis of trisubstituted furans. It is also a reactant for the fluorination by HF and iodosylbenzene, intramolecular Michael addition reactions and synthesis of diols. Also applied in the synthesis of diols via reduction of aromatic and aliphatic ketos esters6 and cross-coupling reactions for stereo selective synthesis of unsymmetrical 1,4-enediones.
UsesReactant involved in:
  • Synthesis of β-1,3-dicarbonyl aldehydes via oxidation
  • Knoevenagel condensation using a lysine catalyst
  • Cycloisomerization fo rthe synthesis of trisubstituted furans
  • Fluorination by HF and iodosylbenzene
  • Intramolecular Michael addition reactions for synthesis of benzylbutyrolactones
  • Synthesis of diols via reduction of aromatic and aliphatic ketos esters
  • Cross-coupling reactions for stereoselective synthesis of unsymmetrical 1,4-enediones
ETHYL 4-NITROBENZOYLACETATE Preparation Products And Raw materials
Preparation ProductsDIMETHYL-5-(P-NITROBENZOYLACETAMINO)ISOPHTHALATE-->Benzenepropanoic acid, 4-aMino-b-oxo-, ethyl ester
4-ETHOXY-2-BUTANONE 1-NITRO-4-N-PROPYLBENZENE ETHYL 3-(4-AMINOPHENYL)PROPANOATE 3-(4-AMINO-PHENYL)-PROPAN-1-OL 4'-AMINOPROPIOPHENONE 3-Phenylpropionic acid methyl ester 1-(4-NITROPHENYL)PROPAN-1-ONE 3-OXO-3-PHENYL-PROPIONALDEHYDE 4-Nitroacetophenone Benzenamine, 4-ethyl-N-hydroxy- (9CI) Methyl acetoacetate 4-PROPYLANILINE ETHYL 4-NITROBENZOATE METHYL 3-OXO-3-PHENYLPROPANOATE 3-(4-NITRO-PHENYL)-PROPIONALDEHYDE 3-(4-AMINOPHENYL)PROPIONIC ACID ETHYL 4-NITROBENZOYLACETATE 3-(4-NITRO-PHENYL)-PROPIONIC ACID ETHYL ESTER

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