Toloxatone

Toloxatone Basic information

Product Name:	Toloxatone
Synonyms:	2-OXAZOLIDINONE, 5-(HYDROXYMETHYL)-3-(3-METHYLPHENYL)-;Toloxatone;ToloxatonetoloxatonetoloxatoneToloxatone;5-Hydroxymethyl-3-(3-methylphenyl)oxazolidin-2-one;Humoryl;MD-69276;Perenum;5-(Hydroxymethyl)-3-(m-tolyl)oxazolidin-2-one
CAS:	29218-27-7
MF:	C11H13NO3
MW:	207.23
EINECS:	249-522-2
Product Categories:
Mol File:	29218-27-7.mol

Toloxatone Chemical Properties

Melting point	76°
Boiling point	358.9±21.0 °C(Predicted)
density	1.245±0.06 g/cm3(Predicted)
storage temp.	Inert atmosphere,2-8°C
solubility	DMSO: >10mg/mL
form	solid
pka	14.05±0.10(Predicted)

Safety Information

Hazard Codes	Xn
Risk Statements	22
RIDADR	3249
WGK Germany	3
RTECS	RQ2867500
HazardClass	6.1(b)
PackingGroup	III
Toxicity	LD50 orally in mice (mg/kg): 1850 (Fauran); also reported as 1500 (Raynaud)

MSDS Information

Toloxatone Usage And Synthesis

Description	Toloxatone is a selective, reversible and competitive inhibitor of type A monoamine oxidase (MAO-A) which shows clinical utility as an antidepressant. It is reportedly free of the "cheese effect" in man, possibly due to the reversible nature of its inhibitory effect on intestinal MAO-A in the presence of high concentrations of tyramine.
Originator	Delalande (France)
Uses	Toloxatone is a monoamine oxidase-A (MAO-A) inhibitor.
Definition	ChEBI: 5-(hydroxymethyl)-3-(3-methylphenyl)-1,3-oxazolidin-2-one is a member of the class of oxazolidinones that is 5-(hydroxymethyl)-1,3-oxazolidin-2-one substituted by a 3-methylphenyl group at position 3. It is a member of toluenes, an oxazolidinone and a primary alcohol.
Brand name	HUMORYL

Toloxatone Preparation Products And Raw materials

Raw materials

Propylene oxide-->Propylene glycol-->m-Toluidine-->Methyl chloroformate

Duloxetine 2-Oxazolidinone, 5-hydroxymethyl-3-(m-tolyl)-, carbamate HYDROXYPROPYLCARBAMATE 3-PHENYL-2-OXAZOLIDINONE Toloxatone

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