12-Crown-4

12-Crown-4 Basic information
Product Name:12-Crown-4
Synonyms:LITHIUM IONOPHORE V;CROWN ETHER/12-CROWN-4;Crown;Eoct;Ethylene oxide cyclic tetramer;1,4,7,10-TETRAOXYCYCLODODECANE;1,4,7,10-TETRAOXACYCLODODECANE;12-CROWN 4-ETHER
CAS:294-93-9
MF:C8H16O4
MW:176.21
EINECS:206-036-5
Product Categories:Crown Ethers;Functional Materials;Macrocycles for Host-Guest Chemistry
Mol File:294-93-9.mol
12-Crown-4 Structure
12-Crown-4 Chemical Properties
Melting point 16 °C (lit.)
Boiling point 61-70 °C/0.5 mmHg (lit.)
density 1.089 g/mL at 25 °C (lit.)
refractive index n20/D 1.463(lit.)
Fp >230 °F
storage temp. Keep in dark place,Sealed in dry,Room Temperature
form Liquid After Melting
color Clear colorless to slightly yellow
Specific Gravity1.115 (20℃)
Water Solubility MISCIBLE
Sensitive Air Sensitive
BRN 1363064
CAS DataBase Reference294-93-9(CAS DataBase Reference)
NIST Chemistry Reference12-Crown-4(294-93-9)
EPA Substance Registry System1,4,7,10-Tetraoxacyclododecane (294-93-9)
Safety Information
Hazard Codes T+,Xn,Xi
Risk Statements 26-36/37/38-20/21/22
Safety Statements 28-36/37-45-36-26
RIDADR UN 2810
WGK Germany 3
RTECS XF0550000
3-9-23
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29329995
ToxicityLD50 oral in rat: 2830mg/kg
MSDS Information
ProviderLanguage
1,4,7,10-Tetraoxacyclododecane English
ACROS English
SigmaAldrich English
ALFA English
12-Crown-4 Usage And Synthesis
Chemical Propertiesclear colorless to slightly yellow liquid after
UsesIt serves as an aprotic "solvent" for alkali metals, the sodium solution is a strong reducing agent.
Uses12-Crown-4 can be used as:
  • A promoter in the synthesis of poly(diethylsiloxane) (PDES) from monomer hexaethylcyclotrisiloxane using NaOH as a catalyst via anionic ring-opening polymerization.
  • As an additive in the preparation of triarylmethane derivatives by palladium-catalyzed cross coupling reaction of aryl bromides with diarylmethane derivatives.
  • A phase transfer catalyst in organic synthesis.

DefinitionChEBI: A crown ether that is cyclododecane in which the carbon atoms at positions 1, 4, 7 and 10 have been replaced by oxygen atoms.
Synthesis Reference(s)Tetrahedron Letters, 15, p. 4029, 1974 DOI: 10.1016/S0040-4039(01)92075-1
General Description12-Crown-4 is a crown ether generally used as a ligand in coordination chemistry. It is also known as lithium ionophore because of its strong chelating property specific to lithium cation.
Purification MethodsThe distilled crude product has to be recrystallised from pentane at -20o to remove acyclic material. It is then dried over P2O5. It complexes Li. [Anet et al. Acta Chem Scand 27 3395 1973, Beilstein 19/11 V 334.]
12-Crown-4 Preparation Products And Raw materials
4-TERT-BUTYL-CALIX[4]ARENE-CROWN-4-COMPLEX 1-AZA-12-CROWN 4-ETHER,1-AZA-12-CROWN-4,AZA-12-CROWN-4,aza-12-crown-499.5+% CYCLOHEXANO-12-CROWN-4 (CIS TRANS),cyclohexano-12-crown-493%mixtureofcisandtrans,CYCLOHEXANO-12-CROWN-4, MIXTURE OF CIS AND TRANS, 93 (+/-)-2-(aminoethyl)-12-crown-4 2-Methyl-2-[bromomethyl]-1,4,7,10-tetraoxacyclododecane 2,3-NAPHTHO-12-CROWN-4 HEXAFLUOROPROPYLENE OXIDE TETRAMER ACID FLUORIDE BIS[(12-CROWN-4)METHYL] 2,2-DIDODECYLMALONATE Tetraaza 12-crown-4 CYCLOHEXANO-12-CROWN-4 N-METHYLAZA-12-CROWN-4 2-(HYDROXYMETHYL)-12-CROWN 4-ETHER 1,7-DIAZA-12-CROWN-4,4,10-DIAZA-12-CROWN 4-ETHER BIS[(12-CROWN-4)METHYL] DODECYLMETHYLMALONATE 2-Methyl-2-[(2-methoxyethoxy)methyl]-1,4,7,10-tetraoxacyclododecane 12-Crown-4 SODIUM IONOPHORE VIII EPOXYPROPYLENE, TETRAMER

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