|
| | Hederagenin Basic information |
| | Hederagenin Chemical Properties |
| Melting point | 332-334° | | alpha | D20 +81° (c = 0.7 in pyridine) | | Boiling point | 493.44°C (rough estimate) | | density | 0.9871 (rough estimate) | | refractive index | 1.4800 (estimate) | | storage temp. | Sealed in dry,2-8°C | | solubility | methanol: soluble1mg/mL | | pka | 4.63±0.70(Predicted) | | form | Solid | | color | White to Off-White | | λmax | 405nm(H2SO4)(lit.) | | Merck | 14,4624 | | InChIKey | PGOYMURMZNDHNS-MYPRUECHSA-N | | LogP | 7.410 (est) |
| Hazard Codes | Xi | | Risk Statements | 22 | | Safety Statements | 22-45-24/25 | | WGK Germany | 3 | | HS Code | 29181990 |
| | Hederagenin Usage And Synthesis |
| Description | Hederagenin is a triterpene saponin that has been found in P. eximia with diverse biological activities. It increases production of reactive oxygen species (ROS), reduces colony formation, and induces apoptosis in cisplatin-resistant head and neck carcinoma (HNC) cells. In vivo, hederagenin (50, 100, and 200 mg/kg) suppresses tumor growth in a cisplatin-resistant HNC mouse xenograft model. It reduces aortic atherosclerotic lesion area, serum cholesterol and LDL levels, and inducible nitric oxide synthase (iNOS) protein levels in a rat model of atherosclerosis. Hederagenin (50 mg/kg) reduces ethanol-induced production of TNF-α, IL-6, and COX-2, alcohol dehydrogenase 2 (ALDH2) mRNA expression, and liver damage in a rat model of alcohol-induced hepatotoxicity. It also induces autophagy and inhibits oligomerization of α-synuclein in a mouse model of Parkinson''s disease induced by MPTP. | | Chemical Properties | White Solid | | Uses | Triterpenoid which can inhibit the proliferation of leukemia HL-60 cells. | | Definition | ChEBI: A sapogenin that is olean-12-en-28-oic acid substituted by hydroxy groups at positions 3 and 23 (the 3beta stereoisomer). |
| | Hederagenin Preparation Products And Raw materials |
|
