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| Product Name: | CARNOSOL | | Synonyms: | 1,3,4,9,10,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE;1,3,4,9,10AS-HEXAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISO-PROPYL-2H-9S,4AR-(EPOXYMETHANO)PHENANTHREN-12-ONE;1,2,3,4,4A,9,10,10AS-OCTAHYDRO-5,6-DIHYDROXY-1,1-DIMETHYL-7-ISOPROPYL-9S, 4AR (EPOXYMETHANO)PHENANTHREN-12-ONE;CARNOSOL(RG);CARNOSOL;Carnosol, froM RoseMarinus officinalis;Carnosol, 98%, from Rosemarinus officinalis;2H-9,4a-(Epoxymethano)phenanthren-12-one, 1,3,4,9,10,10a-hexahydro-5,6-dihydroxy-1,1-dimethyl-7-(1-methylethyl)-, (4aR,9S,10aS)- | | CAS: | 5957-80-2 | | MF: | C20H26O4 | | MW: | 330.42 | | EINECS: | | | Product Categories: | chemical reagent;pharmaceutical intermediate;Miscellaneous Natural Products;Antioxidant;Biochemicals Found in Plants;Nutrition Research;phytochemical;reference standards from Chinese medicinal herbs (TCM).;standardized herbal extract | | Mol File: | 5957-80-2.mol |  |
| | CARNOSOL Chemical Properties |
| Melting point | 240～242℃ | | Boiling point | 524.8±50.0 °C(Predicted) | | density | 1.26±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | solubility | DMSO:66.0(Max Conc. mg/mL);199.74(Max Conc. mM) | | pka | 8.91±0.40(Predicted) | | form | neat | | color | White | | LogP | 2.832 (est) |
| | CARNOSOL Usage And Synthesis |
| Description | Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen. | | Description | Carnosol is a phenol that has been found in rosemary (R. officinalis) and has diverse biological activities. It decreases nitric oxide (NO) production in mouse peritoneal exudate macrophages when used at concentrations ranging from 6 to 25 μM. Carnosol scavenges peroxyl and hydroxyl radicals and inhibits lipid peroxidation in cell-free assays. It inhibits 5-lipoxygenase (5-LO; IC50 = 0.1 μM for the recombinant human enzyme) and the synthesis of leukotrienes in human polymorphonuclear leukocytes (PMNs; IC50 = 7 μM). In vivo, carnosol (200 mg/kg) reduces mammary DNA adduct formation and tumorigenesis in a rat model of DMBA-induced mammary tumorigenesis. | | Chemical Properties | White powder | | Uses | Carnosol is a phytopolyphenol found in Rosemary that functions as an antioxidant, antimicrobial, & anticarcinogen. | | Definition | ChEBI: Carnosol is a diterpenoid. | | Cytotoxicity | IC50 (μg/mL): 65 (HL-60), 58 (K562), 50(Hep G2), 48 (MCF-7), 53 (MOLT-4)(Farimani et al. 2012)
IC50 (μg/mL): 61.46 (AGS) (Areche et al.2009)
IC50 (μg/mL): 2 (P388) (Aoyagi et al.2006)
IC50 (μg/mL): 1.19 (A2780), 3.30(SW1573), 8.59 (WiDr), 7.93 (T-47D),1.29 (HBL-100) (Guerrero et al. 2006). |
| | CARNOSOL Preparation Products And Raw materials |
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