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| | Calcifediol Monohydrate Basic information |
| | Calcifediol Monohydrate Chemical Properties |
| Fp | 14℃ | | storage temp. | -20°C | | solubility | Practically insoluble in water, freely soluble in ethanol (96 per cent), soluble in fatty oils. | | form | neat | | color | White to Light yellow | | BRN | 4270041 | | InChIKey | JWUBBDSIWDLEOM-LCDSLSDMSA-N | | SMILES | C[C@]12CCC/C(=C\C=C3\C[C@@H](O)CCC\3=C)/[C@]1([H])CC[C@]2([H])[C@H](C)CCCC(O)(C)C.O |&1:1,10,16,20,22,r| | | CAS DataBase Reference | 63283-36-3(CAS DataBase Reference) |
| | Calcifediol Monohydrate Usage And Synthesis |
| Chemical Properties | White or almost white crystals. | | Uses | Calcifediol is a major circulating metabolite of vitamin D3 and acts as a competitive inhibitor with an apparent Ki of 3.9 μM. It is produced in the liver and is the best indicator of the body’s vitamin D stores. It is effective in the treatment of ricket | | Uses | 25-Hydroxyvitamin D3 may be used as a certified reference material (CRM) for the determination of the analyte in biological samples by chromatography techniques. | | Definition | ChEBI: Calcifediol monohydrate is a vitamin D. | | Brand name | Calderol (Organon). | | General Description | A Certified Spiking Solution? of 25-Hydroxyvitamin D3, a prohormone whose blood serum levels are used to determine Vitamin D nutritional status. This solution standard is suitable for critical quantitative applications in research and clinical environments including: for use in preparation of controls and calibrators for LC/UV and LC-MS/MS assays; as system tuning/suitability standards; linearity verification; internal proficiency testing; and for OEM use in preparation of reagents, development of assays and instrument IQ/OQ. The stable, quantitative solution format provides significant benefits to the user including material savings, increased efficiency of labor, and convenience of use. The shelf stable Snap-N-Spike? format allows laboratories to eliminate painstaking weighing operations and provides the ability to spike a known concentration of analyte into their matrix of choice just before use. | | Biochem/physiol Actions | Cholecalciferol is an inactive form of vitamin D3 which undergoes various levels of hydroxylation to form active vitamin D3 analogs. 1α-Hydroxyvitamin D3 (alfacalcidol) is a synthetic analog that is metabolized to 1,25-dihydroxycholecalciferol, the biologically active form of vitamin D3. Other analogues of cholecalciferol result from different hydroxylations. 25-dihydroxycholecalciferol is a the major circulating form of vitamin D3 and a physiological precursor of 1α,25-Dihydroxycholecalciferol. The conversion is catalyzed by 25-Hydroxyvitamin D3 1-α-hydroxylase (VD3 1A hydroxylase) also known ascytochrome p450 27B1 (CYP27B1). | | target | IL Receptor |
| | Calcifediol Monohydrate Preparation Products And Raw materials |
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