4-chloro-6,7-dimethoxyquinoline

4-chloro-6,7-dimethoxyquinoline Basic information
Product Name:4-chloro-6,7-dimethoxyquinoline
Synonyms:6,7-DIMETHOXY-4-CHLOROQUINOLINE;4-CHLORO-6,7-DIMETHOXYQUINOLINE;4-Chloro-6,7-dimethoxyquioline;Quinoline, 4-chloro-6,7-dimethoxy-;4-CHLORO-6,7-DIMETHOXYQUINOLINE(35654-56-9);Cabozantinib 4-Chloroquinoline Impurity;4-Chloro-6,7-dimethoxyquinoline >;oro-6,7-dimethoxyquinoL
CAS:35654-56-9
MF:C11H10ClNO2
MW:223.66
EINECS:676-028-8
Product Categories:Quinoline&Isoquinoline;35654-56-9
Mol File:35654-56-9.mol
4-chloro-6,7-dimethoxyquinoline Structure
4-chloro-6,7-dimethoxyquinoline Chemical Properties
Melting point 132.0 to 136.0 °C
Boiling point 325.2±37.0 °C(Predicted)
density 1.265±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Sealed in dry,Room Temperature
solubility DMSO (Slightly), Methanol (Slightly)
form Solid
pka3.95±0.30(Predicted)
color Pale Brown to Light Brown
InChIInChI=1S/C11H10ClNO2/c1-14-10-5-7-8(12)3-4-13-9(7)6-11(10)15-2/h3-6H,1-2H3
InChIKeyWRVHQEYBCDPZEU-UHFFFAOYSA-N
SMILESN1C2C(=CC(OC)=C(OC)C=2)C(Cl)=CC=1
CAS DataBase Reference35654-56-9(CAS DataBase Reference)
Safety Information
Hazard Codes T
Risk Statements 25
Safety Statements 45-24/25
RIDADR UN2811
HazardClass IRRITANT
HS Code 29334900
MSDS Information
4-chloro-6,7-dimethoxyquinoline Usage And Synthesis
Chemical PropertiesLight brown powder
Uses4-Chloro-6,7-dimethoxyquinoline, can be used as an intermediate for the synthesis of various pharmaceutical and biologically active compounds. It is used for the preparation of Tivozanib (T447205), and Cabozantinib (C051500), acting as anticancer agents.
Application4-chloro-6,7-dimethoxy-quinoline can be rich for Buddhist nun with for Wo Zhani medicine as preparing antitumor drug card The key intermediate of thing molecule synthesis.
SynthesisWith 3,4-dimethoxyaniline is raw material, obtains aniline compound through nitrification, iron powder reducing, then with Ethyl chloroformate, in Feldalat NM condition cyclization, prepares 4-hydroxyquinoline compounds, after through three Chlorethoxyfos chloro obtains 4-chloro-6,7-dimethoxy-quinoline.
4-chloro-6,7-dimethoxyquinoline synthesis
ethyl 4-chloro-5,8-dimethoxyquinoline-3-carboxylate AURORA KA-4511 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBONITRILE ethyl 4-chloro-6,8-dimethoxyquinoline-3-carboxylate 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID ETHYL ESTER 4-CHLORO-5,6,7-TRIMETHOXYQUINOLINE 4-CHLORO-7,8-DIMETHOXYQUINOLINE 4-CHLORO-7-ISOPROPOXY-6-METHOXY-QUINOLINE-3-CARBONITRILE 4-chloro-5,8-dimethoxyquinoline-3-carbonitrile 10-chloro-3,4-dihydro-2H-[1,4]dioxepino[2,3-g]quinoline-9-carbonitrile 4-chloro-6,8-dimethoxyquinoline-3-carbonitrile 2-CHLORO-4,6-DIMETHOXYQUINOLINE ethyl 4-chloro-5,7-dimethoxyquinoline-3-carboxylate 4-Amino-2-Chloro-6,7-Dimethoxyquinoline 4-Chloro-6-methoxy-7-(phenylmethoxy)-3-quinolinecarboxylic acid ethyl ester 4-CHLORO-2-METHYL-5,6,7-TRIMETHOXYQUINOLINE ethyl 4-chloro-6,7-dimethoxyquinoline-3-carboxylate 4-CHLORO-6,7-DIMETHOXY-QUINOLINE-3-CARBOXYLIC ACID

Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.