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| | Vanillyl alcohol Basic information |
| | Vanillyl alcohol Chemical Properties |
| Melting point | 110-117 °C (lit.) | | Boiling point | 237.52°C (rough estimate) | | density | 1.1690 (rough estimate) | | refractive index | 1.4620 (estimate) | | FEMA | 3737 | VANILLYL ALCOHOL | | storage temp. | Inert atmosphere,Room Temperature | | solubility | soluble in Methanol | | form | Fine Crystalline Powder | | pka | 9.75±0.18(Predicted) | | color | Off-white to beige | | Odor | at 100.00 %. sweet creamy vanilla caramellic coconut graham cracker tonka milky powdery | | Odor Type | creamy | | Water Solubility | Soluble in 95% ethanol (5 %), water, and oils. | | JECFA Number | 886 | | BRN | 1910044 | | Stability: | Stable. Incompatible with strong oxidizing agents, strong acids. | | LogP | 0.42 | | CAS DataBase Reference | 498-00-0(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Hydroxy-3-methoxybenzyl alcohol(498-00-0) |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26-36 | | WGK Germany | 3 | | Hazard Note | Irritant | | HS Code | 29095090 |
| | Vanillyl alcohol Usage And Synthesis |
| Description | 4-hydroxy-3-methoxybenzyl alcohol (also known as vanillyl alcohol) is often used as a deodorant component that is active in preventing the formation of body odor. It can also be used as a flavoring agent. Recent studies have also demonstrated that it has certain pharmacological effects. For example, it has been confirmed that it has certain neuro-protective effects through suppressing the oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells, making it a potential candidate for the treatment of neurodegenerative diseases such as Parkinson’s disease.
| | Chemical Properties | crystalline white to off-white powder | | Chemical Properties | Vanillyl alcohol has a mild, sweet, balsamic, vanilla-like odor. | | Uses | Used as a flavoring agent. Other possible uses, vanilla, coconut, cream and other dairy nuances, coumarin. | | Definition | ChEBI: Vanillyl alcohol is a monomethoxybenzene that is 2-methoxyphenol substituted by a hydroxymethyl group at position 4. It has a role as a plant metabolite. It is a member of guaiacols and a member of benzyl alcohols. | | Taste threshold values | Sweet, creamy and milky with a slightly powdery mouthfeel. | | General Description | Vanillyl alcohol belongs to the phenolic group of compounds which are widely used as oxidants in food products. | | Biochem/physiol Actions | Odor at 1.0%: sweet creamy, phenolic, vanilla and coconut-like with slight brown and coumarinic nuances. | | References | Brune, I, et al. "Under the influence of the active deodorant ingredient 4-hydroxy-3-methoxybenzyl alcohol, the skin bacterium Corynebacterium jeikeium moderately responds with differential gene expression." Journal of Biotechnology 127.1(2006):21-33.
Hsu, Lun Chung, Z. H. Wen, and K. Y. Lee. "Use of vanillyl alcohol for the treatment of Parkinson's disease." (2009).
Kim, I. S., D. K. Choi, and H. J. Jung. "Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells." Molecules 16.7(2011):5349.
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| | Vanillyl alcohol Preparation Products And Raw materials |
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