|
| | METHYL 4-CHLOROBENZOATE Basic information |
| | METHYL 4-CHLOROBENZOATE Chemical Properties |
| Melting point | 42-44 °C (lit.) | | Boiling point | 136-137°C 10mm | | density | 1,382 g/cm3 | | refractive index | 1.5800 (estimate) | | Fp | 224 °F | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | solubility | Chloroform (Slightly), Methanol (Slightly) | | form | Solid | | color | Off-White | | Merck | 14,2125 | | BRN | 1564310 | | LogP | 2.870 | | CAS DataBase Reference | 1126-46-1(CAS DataBase Reference) | | EPA Substance Registry System | Benzoic acid, 4-chloro-, methyl ester (1126-46-1) |
| Risk Statements | 36/37/38 | | Safety Statements | 24/25 | | WGK Germany | 3 | | TSCA | Yes | | HazardClass | IRRITANT | | HS Code | 29163990 |
| | METHYL 4-CHLOROBENZOATE Usage And Synthesis |
| Chemical Properties | COLOURLESS TO WHITE CRYSTALS | | Uses | Methyl 4-chlorobenzoate was used in quantitative determination of chlorophenoxyisobutyrate (CPIB) and salicylic acid, the metabolites of clofibrate and aspirin, by GC-MS method. | | Synthesis Reference(s) | Synthesis, p. 790, 1981 DOI: 10.1055/s-1981-29595 | | General Description | Methyl 4-chlorobenzoate undergoes room temperature Pd-mediated hydrodehalogenation with KF and polymethylhydrosiloxane (PMHS) to yield methyl benzoate. It undergoes Suzuki-Miyaura coupling reaction with phenylboronic acid in the presence of bis-carbene palladium complex catalyst to yield methyl-(4-phenyl)-benzoate. |
| | METHYL 4-CHLOROBENZOATE Preparation Products And Raw materials |
| Raw materials | Benzamide, 4-chloro-N-methoxy--->4-chloro-N,N-dimethylbenzamide-->4-Chlorobenzyl alcohol-->1-(4-Chlorophenyl)ethanol-->4-CHLOROBENZANILIDE | | Preparation Products | 1,2,3-BENZOTHIADIAZOLE-5-CARBOXYLIC ACID-->4-CHLOROBENZOYLACETONITRILE-->SODIUM P-CHLOROBENZOATE-->4-(Butylamino)-benzoic acid, methyl ester-->3-(4-CHLOROPHENYL)-1H-PYRAZOL-5-AMINE-->METHYL 4-VINYLBENZOATE-->Methyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzoate-->3-amino-1-(4-chlorophenyl)propan-1-ol-->4-Chloro-N-n-hexylbenzaMide, 97% |
|
