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| | 3-DEAZAADENOSINE Basic information |
| Product Name: | 3-DEAZAADENOSINE | | Synonyms: | 3-DEAZAADENOSINE;4-AMINO-1-[BETA-D-RIBOFURANOSYL]-1H-IMIDAZO[4,5]-PYRIDINE;4-Amino-1-(D-ribofuranosyl)-1H-imidazo(4,5)-pyridine;1H-Imidazo4,5-cpyridin-4-amine, 1-.beta.-D-ribofuranosyl-;3-Deaza-D-adenosine;NSC 167897;(2R,3R,4S,5R)-2-(4-AMino-1H-iMidazo[4,5-c]pyridin-1-yl)-5-(hydroxyMethyl)tetrahydrofuran-3,4-diol;3-Deaza-rA | | CAS: | 6736-58-9 | | MF: | C11H14N4O4 | | MW: | 266.25 | | EINECS: | | | Product Categories: | Bases & Related Reagents;Inhibitors;Nucleotides | | Mol File: | 6736-58-9.mol |  |
| | 3-DEAZAADENOSINE Chemical Properties |
| Melting point | 228-229°C | | Boiling point | 665.7±65.0 °C(Predicted) | | density | 1.90±0.1 g/cm3 (20 ºC 760 Torr) | | storage temp. | Keep in dark place,Inert atmosphere,2-8°C | | solubility | H2O: 10 mg/mL with heating to 60 °C | | pka | 13.24±0.70(Predicted) | | form | Solid | | color | White to Off-White |
| Safety Statements | 24/25 | | RIDADR | 2811 | | WGK Germany | 3 | | HazardClass | 6.1(a) | | PackingGroup | II | | HS Code | 29419090 |
| | 3-DEAZAADENOSINE Usage And Synthesis |
| Description | 3-Deazaadenosine (3-DZA) is an inhibitor of SAH (Sadenosylhomocysteine) hydrolase (Ki = 3.9 μM). It has antiinflammatory properties, inhibiting leukocyte adhesion and chemotaxis, lymphocyte-mediated cytolysis, phagocytosis, degranulation, and NF-κB signaling. 3-DZA also has anti-viral and anti-bacterial activities. | | Chemical Properties | Bright Yellow Solid | | Uses | Possesses antiviral activity. It is an inhibitor of leukocyte adhesion to TNF-treated endothelial cells. | | Biochem/physiol Actions | Possesses antiviral activity inhibitor of leukocyte adhesion to TNF-treated endothelial cells. | | in vitro | 3-deazaadenosine showed inhibitory values against the ebo-z viruses, ebo, and marburg virus in various cell lines of primate (sw13, vero 76, frhl, llc-mk2, mrc-5, vero e6) and mouse (balb/3t3 clone a31) origin. 3-deazaadenosine at 2 μg/ml could reduce viral replication by 3 logs in a dose-dependent manner. however, there was no further inhibition even with a 100-fold increase in concentration [1]. | | in vivo | in vehicle control group, adult balb/c mice lethally infected with mouse-adapted ebola virus die 5-7 days after infection. in contrast, 3-deazaadenosine treatment initiated on day 0 or 1 led to a dose-dependent protection, with mortality completely prevented at doses around 0.7 mg/kg every 8 h. moreover, there was significant protection when 3-deazaadenosine treatment was begun on day 2, at which time, the spleen had an average titer of 2 × 106 pfu/g and the liver had 3 × 105 pfu/g virus. treatment with 3-aeazaadenosine at 2.2 mg/kg initiated on day 3 resulted in 40% survival [1]. | | references | [1] huggins, z. x. zhang and m. bray. antiretroviral drug therapy of filovirus infections: s-adenosylhomocysteine hydrolase inhibitors inhibit ebola virus in vitro and in a lethal mouse model. journal of infectious diseases 179 (1), s240-s247 (1999). |
| | 3-DEAZAADENOSINE Preparation Products And Raw materials |
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