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| | METFORMIN-D6, HYDROCHLORIDE Basic information |
| | METFORMIN-D6, HYDROCHLORIDE Chemical Properties |
| Melting point | 215-218°C | | storage temp. | -20°C Freezer | | solubility | Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | neat | | color | White to Off-White |
| Hazard Codes | Xn | | Risk Statements | 22-36/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| | METFORMIN-D6, HYDROCHLORIDE Usage And Synthesis |
| Description | Metformin-d6 is intended for use as an internal standard for the quantification of metformin by GC- or LC-MS. Metformin is a biguanide with diverse biological activities. Metformin (250 mg/kg, i.p.) increases hepatic AMPK activity and reduces blood glucose by more than 50% in a liver kinase B1-dependent manner in mice fed normal and high-fat diets, respectively, and reduces blood glucose by 40% in ob/ob mice. It reduces weight gain, hepatic lipid droplet content, and total cholesterol, LDL cholesterol, and triglyceride levels in the plasma of diet-induced obese mice when administered at doses of 10 or 50 mg/kg per day. It also reverses increased hepatic triglyceride and apolipoprotein A5 levels, as well as hepatic steatosis, in a dose-dependent manner in an ob/ob mouse model of non-alcoholic fatty liver disease (NAFLD). Metformin (250 mg/kg) reduces tumor growth in an HCT116 p53-\- human colon cancer mouse xenograft model, but has no effect on HCT116 p53-\- tumors overexpressing recombinant S. cerevisiae Ndi1 NADH dehydrogenase, a single-subunit ortholog of the multi-subunit mammalian mitochondrial complex I. Formulations containing metformin have been used in the treatment of type 2 diabetes. | | Chemical Properties | White Crystalline Solid | | Uses | An oral hypoglycemic agent. |
| | METFORMIN-D6, HYDROCHLORIDE Preparation Products And Raw materials |
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