Ezetimibe-28

Ezetimibe-28 Basic information
Product Name:Ezetimibe-28
Synonyms:Ezetimibe Impurity 73;Ezetimibe-28;Ezetimibe impuriry 27/(S)-3-((R)-2-((S)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-4-(2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one;(S)-3-((R)-2-((S)-(4-((tert-butyldimethylsilyl)oxy)phenyl)((4-fluorophenyl)amino)methyl)-4-(2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl)butanoyl)-4-phenyloxazolidin-2-one;Ezetimibe Impuriry 73;2-Oxazolidinone, 3-[(2R)-2-[(S)-[4-[[(1,1-dimethylethyl)dimethylsilyl]oxy]phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-1-oxobutyl]-4-phenyl-, (4S)-
CAS:1478663-95-4
MF:C44H52F2N2O6Si
MW:770.98
EINECS:
Product Categories:
Mol File:1478663-95-4.mol
Ezetimibe-28 Structure
Ezetimibe-28 Chemical Properties
Boiling point 793.6±60.0 °C(Predicted)
density 1.178±0.06 g/cm3(Predicted)
pka3.31±0.50(Predicted)
Safety Information
MSDS Information
Ezetimibe-28 Usage And Synthesis
Uses(4S)-3-[(2R)-2-[(S)-[4-[[(1,1-Dimethylethyl)dimethylsilyl]oxy]phenyl][(4-fluorophenyl)amino]methyl]-4-[2-(4-fluorophenyl)-5,5-dimethyl-1,3-dioxan-2-yl]-1-oxobutyl]-4-phenyl-2-oxazolidinone is an intermediate in the synthesis of (3’R,3R,4R)-Ezetimibe (E974990), a structural analog of Ezetimibe (E975000). Ezetimibe is an antihyperlipoproteinemic and a cholesterol absorption inhibitor.
Ezetimibe-28 Preparation Products And Raw materials
EzetiMibe (3R,4R,3'S)-IsoMer (R)-3-((S)-5-(4-fluorophenyl)-5-hydroxypentanoyl)-4-phenyloxazolidin-2-one (4S)-3-(2,2-dimethylpropanoyl)-4-phenyl-1,3-oxazolidin-2-one 5-(2-FLUOROPHENYL)-5-OXOVALERIC ACID Ezetimibe Impurity 72 N-(4-(Benzyloxy)benzylidene)-4-fluoroaniline Ezetimibe Impurity 38 Ezetimibe Impurity 79 (αR,δS)-4-Fluoro-N-(4-fluorophenyl)-δ-hydroxy-α-[(4-hydroxyphenyl)Methyl]benzenepentanaMide (3S,4S)-1-(4-fluorophenyl)-3-((S)-3-(4-fluorophenyl)-3-hydroxypropyl)-4-(4-hydroxyphenyl)azetidin-2-one 3-[(2R,5S)-5-(4-Fluorophenyl)-2-[(S)-[(4-fluorophenyl(amino)]][4-[trimethylsilyl]-oxy]phenyl]methyl]-1-oxo-5-[(trimethylsily)-oxy]pentyl]-4-phenyl-(4S)-2-oxazolidinone Ezetimibe Impurity 71 (R)-(-)-4-Phenyl-2-oxazolidinone EzetiMibe Azetidinone Ring-opened IMpurity EzetiMibe IMpurity 1 Ezetimibe (RSS)-Isomer Ezetimibe Impurity 35 Ezetimibe Impurity 78

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