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| Product Name: | NU7026 | | Synonyms: | DNA-PK Inhibitor II - CAS 154447-35-5 - Calbiochem;NU 7026; NU-7026;CS-595;2-MORPHOLINO-4H-BENZO[H]CHROMEN-4-ONE;NU7026, >=98%;2-(4-Morpholinyl)-4H-naphthol[1,2-b]pyran-4-one;NU7026;LY293646; NU-7026;LY 293646 | | CAS: | 154447-35-5 | | MF: | C17H15NO3 | | MW: | 281.31 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 154447-35-5.mol |  |
| | NU7026 Chemical Properties |
| Melting point | 267-269 °C(Solv: methanol (67-56-1); water (7732-18-5)) | | Boiling point | 459.9±45.0 °C(Predicted) | | density | 1.330 | | storage temp. | 2-8°C | | solubility | DMSO: 3 mg/mL at 60 °C, soluble | | pka | 0.49±0.20(Predicted) | | form | solid | | color | tan |
| | NU7026 Usage And Synthesis |
| Uses | DNA-PK Inhibitor II is an antiproliferative agent, and inhibitor of DNA-PK. | | Uses | NU7026 has been used:
- as a DNA-dependent protein kinase (DNA-PK) inhibitor, to pre-treat colon cancer cell
- in kinase inhibitor experiments for treating zygotes with visible pronuclei post 20 h-human chorionic gonadotropin (hCG)
- to determine its influence on cytotoxicity of dibenzo[def,p]chrysene on HepG2 cells
| | Definition | ChEBI: 2-(4-morpholinyl)-4-benzo[h][1]benzopyranone is an organooxygen compound and an organic heterotricyclic compound. | | Biological Activity | ATP-competitive inhibitor of DNA-dependent protein kinase (DNA-PK). Displays selectivity over other PIKK family enzymes (IC 50 values are 0.23, 13.0, > 100 and > 100 μ M for DNA-PK, PI3K, ATM and ATR respectively). Radiosensitizes both proliferating and quiescent mouse embryonic fibroblast cells to IR and inhibits DSB repair. | | Biochem/physiol Actions | Cell permeable, small molecule benzochromenone inhibitor of DNA-PK (DNA dependent protein kinase). | | storage | Store at +4°C |
| | NU7026 Preparation Products And Raw materials |
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