ChemicalBook Product Catalog Food Additives Thickener CARBOXYMETHYLCELLULOSE CALCIUM

CARBOXYMETHYLCELLULOSE CALCIUM

CARBOXYMETHYLCELLULOSE CALCIUM Basic information
Product Name:CARBOXYMETHYLCELLULOSE CALCIUM
Synonyms:hylon600;CMCCalcium;CALCIUMCARBOXYLMETHYLCELLULOSE;Calciam carboxymethylceUulose;Carboxymethylcellulose calcium (nf);Carmellose calcium (jp15);D03400;carboxyMethyl cellose calciuM
CAS:9050-04-8
MF:C23H30ClN3O
MW:399.9568
EINECS:
Product Categories:
Mol File:9050-04-8.mol
CARBOXYMETHYLCELLULOSE CALCIUM Structure
CARBOXYMETHYLCELLULOSE CALCIUM Chemical Properties
solubility Practically insoluble in acetone, chloroform, ethanol (95%), toluene, and ether. Insoluble in water, but swells to form a suspension.
EPA Substance Registry SystemCellulose, carboxymethyl ether, calcium salt (9050-04-8)
Safety Information
HS Code 3912310000
MSDS Information
CARBOXYMETHYLCELLULOSE CALCIUM Usage And Synthesis
Chemical PropertiesCarboxymethylcellulose calcium occurs as a white to yellowishwhite, hygroscopic, odorless powder.
Chemical PropertiesDS 0.5-0.7
UsesPharmaceutic aid (tablet disintegrant).
Production MethodsCellulose, obtained from wood pulp or cotton fibers, is carboxymethylated, followed by conversion to the calcium salt. It is then graded on the basis of its degree of carboxymethylation and pulverized.
Pharmaceutical ApplicationsThe main use of carboxymethylcellulose calcium is in tablet formulations, where it is used as a binder, diluent, and disintegrant. Although carboxymethylcellulose calcium is insoluble in water, it is an effective tablet disintegrant as it swells to several times its original bulk on contact with water. Concentrations up to 15% w/w may be used in tablet formulations; above this concentration, tablet hardness is reduced.
Carboxymethylcellulose calcium is also used in other applications similarly to carboxymethylcellulose sodium; for example, as a suspending or viscosity-increasing agent in oral and topical pharmaceutical formulations. Carboxymethylcellulose calcium is also used in modern wound dressings for its water absorption, retention and hemostatic properties.
SafetyCarboxymethylcellulose calcium is used in oral and topical pharmaceutical formulations, similarly to carboxymethylcellulose sodium, and is generally regarded as a nontoxic and nonirritant material. However, as with other cellulose derivatives, oral consumption of large amounts of carboxymethylcellulose calcium may have a laxative effect.
storageCarboxymethylcellulose calcium is a stable, though hygroscopic material. It should be stored in a well-closed container in a cool, dry place.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (oral, capsules and tablets). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
CARBOXYMETHYLCELLULOSE CALCIUM Preparation Products And Raw materials
Raw materialsCalcium hydroxide-->Sodium carboxymethyl cellulose
Aluminum acetylacetonate METHYL ISOCYANOACETATE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) N-BUTYLISOCYANIDE PHENYLSELENOL Tris(2,4-pentanedionato)chroMiuM(III) DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) Carboxymethyl cellulose SALCOMINE 2,4-PENTANEDIONE, SILVER DERIVATIVE Tosylmethyl isocyanide COBALT(II) ACETYLACETONATE Cupric acetylacetonate Ethyl isocyanoacetate TERT-BUTYL ISOCYANIDE Ferric acetylacetonate COBALT ETHYLENE DIAMINE CHLORIDE TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)DYSPROSIUM(III)
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