4-Hydroxy-2-butanone

4-Hydroxy-2-butanone Basic information
Product Name:4-Hydroxy-2-butanone
Synonyms:H**4-HYDROXY-2-BUTANONE;2-Butanone, 4-hydroxy-;2-Butanone,4-hydroxy-;3-Ketobutan-1-ol;3-Oxo-1-butanol;3-Oxobutanol;4-Butanol-2-one;4-hydroxy-2-butanon
CAS:590-90-9
MF:C4H8O2
MW:88.11
EINECS:209-693-6
Product Categories:in-stock;straight chain compounds;ketone;1;bc0001;590-90-9
Mol File:590-90-9.mol
4-Hydroxy-2-butanone Structure
4-Hydroxy-2-butanone Chemical Properties
Melting point 15°C (estimate)
Boiling point 73-76 °C/12 mmHg (lit.)
density 1.023 g/mL at 25 °C (lit.)
refractive index 1.430
Fp 91°F
storage temp. under inert gas (nitrogen or Argon) at 2-8°C
solubility Chloroform, Methanol (Slightly)
pka14.43±0.10(Predicted)
form Oil
color Clear Colourless
Water Solubility Miscible with water, alcohol, ethanol and ether.
BRN 1737666
LogP-1.209 at 25℃
CAS DataBase Reference590-90-9(CAS DataBase Reference)
NIST Chemistry Reference4-Hydroxy-2-butanone(590-90-9)
EPA Substance Registry System2-Butanone, 4-hydroxy- (590-90-9)
Safety Information
Risk Statements 10
Safety Statements 16-24/25
RIDADR UN 1993
WGK Germany 3
TSCA Yes
HS Code 29144000
MSDS Information
ProviderLanguage
ALFA English
4-Hydroxy-2-butanone Usage And Synthesis
Chemical PropertiesColourless to pale yellow liquid
Uses4-Hydroxy-2-butanone is used in the preparation of fused benzazepine molecules as selective D3 receptor antagonists with pharmaceutical activity. It is also used in the preparation of verrucarin and mevalonic acid lactone. Further, it is used to prepare 3-buten-2-one through dehydration over an anatase titanium dioxide catalyst. It is also employed in the preparation of 4-methyl-5-hydroxymethylthiazole, (±)-lineatin and beta-hydroxylactones.
DefinitionChEBI: A beta-hydroxy ketone that is butan-2-one substituted by a hydroxy group at position 4.
Application4-Hydroxy-2-butanone has been used in the synthesis of:
  • 3-buten-2-one via dehydration over anatase-TiO2 catalyst
  • 4-methyl-5-hydroxymethylthiazole
  • (±)-lineatin
  • mevalonic acid lactone
  • verrucarin
  • β-hydroxylactones
General Description4-Hydroxy-2-butanone is an important pharmaceutical intermediate. Gas phase reaction of the OH radicals with 4-hydroxy-2-butanone has been investigated by absolute rate method.
Methylparaben Methyl Ethyl 4,4,4-trifluoroacetoacetate Ethyl 2-oxocyclopentanecarboxylate Acetoin Bensulfuron methyl Methyl 4-chloro-3-oxo-butanoate Parathion-methyl 2-Butanone oxime 2-Butanone Kresoxim-methyl Ethyl 2-oxocyclohexanecarboxylate 4-Cyanophenol 4-Hydroxy-2-butanone Methyl acrylate Methyl bromide CHLOROPHOSPHONAZO III 1-HYDROXY-2-BUTANONE

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