1-(2-Hydroxyethyl)piperazine

1-(2-Hydroxyethyl)piperazine Basic information

Product Name:	1-(2-Hydroxyethyl)piperazine
Synonyms:	2-(Piperazin-1-yl)ethan-1-ol, 1-Hydroxy-2-(piperazin-1-yl)ethane;NSC 26884;NSC 38969;NSC 60706;HydroxyethylPiperazine /1-Piperazineethanol;1-Piperazineethanol ,98%;1-(2-Hydroxyethyl)piperazine,2-Piperazinoethanol, Piperazine-1-ethanol;N-(2-Hydroxyethyl)pi
CAS:	103-76-4
MF:	C6H14N2O
MW:	130.19
EINECS:	203-142-3
Product Categories:	Building Blocks;C4 to C8;Piperaizine;Chemical Synthesis;Heterocyclic Building Blocks;Piperazines;103-76-4
Mol File:	103-76-4.mol

1-(2-Hydroxyethyl)piperazine Chemical Properties

Melting point	-38.5 °C
Boiling point	246 °C(lit.)
density	1.061 g/mL at 25 °C(lit.)
vapor pressure	0.007 hPa (20 °C)
refractive index	n20/D 1.506(lit.)
Fp	>230 °F
storage temp.	Store below +30°C.
solubility	Chloroform (Slightly), Methanol (Slightly)
pka	14.96±0.10(Predicted)
form	Oily Liquid
Specific Gravity	1.060
color	Clear colorless to pale yellow
PH	12.3 (100g/l, H2O, 20℃)
explosive limit	1.4-8.9%(V)
Water Solubility	MISCIBLE
BRN	104361
LogP	-1.47 at 25℃
CAS DataBase Reference	103-76-4(CAS DataBase Reference)
NIST Chemistry Reference	1-Piperazineethanol(103-76-4)
EPA Substance Registry System	1-Piperazineethanol (103-76-4)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38-41-38
Safety Statements	26-36/39-37/39
WGK Germany	1
RTECS	TL6825000
Autoignition Temperature	280 °C
Hazard Note	Irritant
TSCA	Yes
HS Code	29335995
Toxicity	LD50 orally in Rabbit: 4000 mg/kg LD50 dermal Rabbit > 5000 mg/kg

MSDS Information

1-(2-Hydroxyethyl)piperazine Usage And Synthesis

Chemical Properties	clear colorless to pale yellow oily liquid
Uses	1-(2-Hydroxyethyl)piperazine is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents.
Uses	1-Piperazineethanol is a hydroxyalkyl substituted pieprazine used in the preparation of pharmaceutical compounds such as neuroleptic agents.
Flammability and Explosibility	Notclassified

1-(2-Hydroxyethyl)piperazine Preparation Products And Raw materials

Raw materials	PIPERAZINE HEXAHYDRATE-->N,N-Bis(2-hydroxyethyl)ethylenediamine-->4-(2-HYDROXYETHYL)-PIPERAZIN-2-ONE-->Nornitrogen mustard-->TERT-BUTYL 4-(2-HYDROXYETHYL)PIPERAZINE-1-CARBOXYLATE-->1-ALLYL-4-(2-HYDROXYETHYL)-PIPERAZINE-->1,4-BIS(2-HYDROXYETHYL)PIPERAZINE-->ETHYLENE OXIDE-->2-Bromoethanol-->Piperazine-->GLYCOLALDEHYDE-->Triethanolamine-->N-(2-Hydroxyethyl)glycine
Preparation Products	Manidipine-->ACETOPHENAZINE MALEATE (200 MG)-->1-(2-Hydroxyethyl)-4-methylpiperazine-->Triethylenediamine-->1-Ethylpiperazine-->2-(4-Benzhydrylpiperazino)ethyl acetoacetate

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