3-(2-Furyl)acrylic acid

3-(2-Furyl)acrylic acid Basic information

Product Name:	3-(2-Furyl)acrylic acid
Synonyms:	(E)-3-(2-furyl)prop-2-enoic acid;2-Furanacrylic acid, (E)-;2-Propenoic acid, 3-(2-furanyl)-, (E)-;AKOS AU36-M220;AKOS BBS-00003729;2-FURANACRYLIC ACID;2-FURALACETIC ACID;Furan-2-acrylic acid, Furfurylideneacetic acid
CAS:	539-47-9
MF:	C7H6O3
MW:	138.12
EINECS:	208-718-8
Product Categories:	Building Blocks;C4 to C7;Chemical Synthesis;Heterocyclic Building Blocks;Heterocycles;Furan&Benzofuran;Organic acids;Heterocyclic Compounds;Furans;Pharmaceutical Intermediates;Aromatic Cinnamic Acids, Esters and Derivatives
Mol File:	539-47-9.mol

3-(2-Furyl)acrylic acid Chemical Properties

Melting point	139-141 °C (lit.)
Boiling point	286 °C (lit.)
density	1.2667 (rough estimate)
refractive index	1.4600 (estimate)
Fp	286°C
storage temp.	Store below +30°C.
solubility	Soluble in dichloromethane and diethyl ether.
pka	4.39±0.10(Predicted)
form	Solid
color	Pale Beige
Water Solubility	2g/L(20 ºC)
Merck	14,4297
BRN	81046
Stability:	Light Sensitive
LogP	1.204 (est)
CAS DataBase Reference	539-47-9(CAS DataBase Reference)
NIST Chemistry Reference	2-Propenoic acid, 3-(2-furanyl)-(539-47-9)
EPA Substance Registry System	2-Propenoic acid, 3-(2-furanyl)- (539-47-9)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25
WGK Germany	3
RTECS	LT8560000
TSCA	Yes
HazardClass	IRRITANT
HS Code	29321900

MSDS Information

Provider	Language
3-(2-Furyl)-2-propenoic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

3-(2-Furyl)acrylic acid Usage And Synthesis

Chemical Properties	white to light yellow crystal powde
Uses	3-(2-Furyl)acrylic acid is a reactant used in the preparation of heteroaryl-substituted bis-trifluoromethyl carbinols and trifluoroacetophenone derivatives malonyl-CoA decarboxylase (MCD) inhibitors.
Uses	3-(2-Furyl)acrylic acid is derivatives used in perfumes.
Synthesis Reference(s)	Journal of the American Chemical Society, 78, p. 3425, 1956 DOI: 10.1021/ja01595a044 Organic Syntheses, Coll. Vol. 3, p. 426, 1955
Purification Methods	Crystallise the cis-isomer from C6H6 and the trans-isomer from H2O, C6H6 or pet ether (b 80-100o)(charcoal). [Beilstein 18 H 301, 18 III/IV 4143, 18/6 V 306.]

3-(2-Furyl)acrylic acid Preparation Products And Raw materials

Raw materials	Malonic acid-->Acrolein
Preparation Products	3-(5-Nitro-2-furyl)acrylic acid-->4,4-DIFLUOROCYCLOHEXANONE-->D-2-FURYLALANINE-->3-ETHYNYL-2-HYDROXY-PHENOL-->4,5-DIHYDRO-4-OXOFURO[3,2-C]PYRIDINE-->ETHYL 3-(2-FURYL)PROPIONATE-->FA-PHE-OME-->1,5-Benzothiazepin-4(5H)-one, 2-(2-furanyl)-2,3-dihydro--->Furo[3,2-c]pyridine-2-carboxaldehyde,4-chloro-

3-Bromofuran 10α-Hydroxy-nalfurafine 3-Furanboronic acid 7,8-Dihydro-14-hydroxy- normorphinone Nalfurafine 2-furanacrylic acid butyl ester 2-furanacrylic acid methyl ester 3-(5-Nitro-2-furyl)acrylic acid Ethyl 2-(Chlorosulfonyl)acetate Ascoric Acid 3-Furylacrylic acid alkyl ester(C=13) ACRYLIC POLYMER Propyl furyl acrylate 2-furanacrylic acid amyl ester 2-furanacrylic acid ethyl ester ETHOXYLATED BISPHENOL A DIACRYLATE 3-(2-Furyl)acrylic acid Poly(acrylic acid)

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