Oxazole

Oxazole Basic information

Description Preparation

Product Name:	Oxazole
Synonyms:	RARECHEM AM LA 0030;OXAZOLE;Oxazole,98+%;3-Azafuran;1,3-Oxazole 98%;EOS-61256;Oxazole>;Oxazole, 98%, for synthesis
CAS:	288-42-6
MF:	C3H3NO
MW:	69.06
EINECS:	206-020-8
Product Categories:	Heterocycle-other series;Oxazole&Isoxazole;Heterocyclic Compounds;Heterocycles;Building Blocks;Heterocyclic Building Blocks;Oxazoles
Mol File:	288-42-6.mol

Oxazole Chemical Properties

Melting point	−87-−84 °C(lit.)
Boiling point	69-70 °C(lit.)
density	1.05 g/mL at 25 °C(lit.)
refractive index	n20/D 1.425(lit.)
Fp	66 °F
storage temp.	Sealed in dry,2-8°C
solubility	Chloroform, Methanol (Slightly)
form	clear liquid
pka	0.8(at 33℃)
color	Colorless to Almost colorless
Water Solubility	Miscible with alcohol and ether. Slightly miscible with water.
BRN	103851
LogP	0.120
CAS DataBase Reference	288-42-6(CAS DataBase Reference)
NIST Chemistry Reference	Oxazole(288-42-6)

Safety Information

Hazard Codes	F,Xi
Risk Statements	11-41-36/37/38
Safety Statements	16-26-36-37/60
RIDADR	UN 1993 3/PG 1
WGK Germany	3
HazardClass	3
PackingGroup	II
HS Code	29349990

MSDS Information

Provider	Language
Oxazole	English
SigmaAldrich	English
ALFA	English

Oxazole Usage And Synthesis

Description	Oxazole is the primary compound for a various class of heterocyclic aromatic organic compounds, which include azoles with a nitrogen and an oxygen separated by one carbon. Oxazole is a weak base and an aromatic compound.
Preparation	There are various methods of synthesizing oxazole in organic chemistry including Van Leusen reaction with TosMIC and aldehydes, Robinson-Gabriel preparation by dehydration of 2-acylaminoketones, and Bredereck reaction with formamide. Oxazole result from the oxidation and cyclization of threonine and serine non-ribosomal peptides.
Chemical Properties	Colorlesstolightyellowliqui
Uses	Oxazole and its derivatives are actively involved as building blocks for bio chemicals and pharmaceuticals like flopristin and darglitazone. It is also involved in industrial applications such as in dyes, fluorescent brightening agents, textile auxiliaries and plastics.
Definition	oxazole: A heterocyclic compoundhaving a nitrogen atom and an oxygenatom in a five-membered ring,C₃H₃NO.
Definition	ChEBI: A five-membered monocyclic heteroarene that is an analogue of cyclopentadiene with O in place of CH2 at position 1 and N in place of CH at position 3.
General Description	Oxazole ring is present in various natural products. The diradical interactions in the ring-opening reaction of oxazole were studied.

Oxazole Preparation Products And Raw materials

Raw materials	diethyl oxazole-4,5-dicarboxylate-->CHLORIDE STANDARD-->Dimethyl oxazole-4,5-dicarboxy-->IFLAB-BB F1963-0009-->2-OXAZOLECARBOXYLIC ACID-->LITHIUM TETRACHLOROAURATE(III)-->4,5-dihydrooxazole-->N-(3-BROMOPROPYL)PHTHALIMIDE-->Oxazole-4-carboxylic acid-->1,3-Cyclopentadiene-->5-Hydroxypyrimidine
Preparation Products	Fluorescent Brightener 185-->Fosthiazate-->LCP polybenzoxazole liquid crystal-->Azamethiphos-->Oxadixyl-->2-(TRI-N-BUTYLSTANNYL)OXAZOLE

2-(4-ISOTHIOCYANATOPHENYL)-PHENANTHRO[9,10-D]OXAZOLE 2-(4'-METHOXY-3-METHYL-BIPHENYL-2-YL)-4,5-DIHYDRO-OXAZOLE 2-(4-BIPHENYL)-5-PHENYLOXAZOLE 98 2-(4-TRIFLUOROMETHYLBENZOYL)OXAZOLE 2-(4-METHYLBENZOYL)OXAZOLE 2-(4-TERT-BUTOXYCARBONYLAMINO-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 2-(4-METHOXY-PHENYL)-OXAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 2-(5-CHLOROVALERYL)OXAZOLE 2-(4-TRIFLUOROMETHYL-BIPHENYL-2-YL)-4,5-DIHYDRO-OXAZOLE 2-(4-PENTYLOXYBENZOYL)OXAZOLE 2-(4-METHOXY-PHENYL)-5-METHYL-4-METHYLSULFANYL-OXAZOLE 2-(4-HEXYLBENZOYL)OXAZOLE 2-(4-NITROBENZOYL)OXAZOLE 2-(4-FLUORO-PHENYL)-OXAZOLE-4-CARBALDEHYDE 2-(4-IODOBENZOYL)OXAZOLE 9,10-DIHYDRO-2-METHYL-4H-BENZO[5,6]CYCLOHEPT[1,2-D]OXAZOL-4-OL 2-(4-ISOPROPYLBENZOYL)OXAZOLE 2-(4-METHOXY-PHENYL)-5-METHYL-OXAZOLE

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