BLASTICIDIN S HYDROCHLORIDE

BLASTICIDIN S HYDROCHLORIDE Basic information
Product Name:BLASTICIDIN S HYDROCHLORIDE
Synonyms:BLASTICIDINE S HYDROCHLORIDE;BLASTICIDIN S HYDROCHLORIDE;BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES;Blasticidine S hydrochloride,Blasticidin S;(S)-4-[[3-amino-5-[(aminoiminomethyl)methylamino]-1-oxopentyl]amino]-1-(4-amino-2-oxo-1(2H)-pyrimidinyl)-1,2,3,4-tetradeoxy-β-D-erythro-Hex-2-enopyranuronic acid,monohydrochloride;Blasticidine S HCl;Blasticidine S hydrochloride solution;Blasticidine S hydrochloride solution,1000ppm
CAS:3513-03-9
MF:C17H27ClN8O5
MW:458.9
EINECS:
Product Categories:Inhibitors;antibiotic
Mol File:3513-03-9.mol
BLASTICIDIN S HYDROCHLORIDE Structure
BLASTICIDIN S HYDROCHLORIDE Chemical Properties
Melting point 224-225 °C (decomp)
storage temp. −20°C
solubility Soluble in Water (greater than 25 mg/ml)
form Liquid
color White
Water Solubility Soluble in water. Insoluble in organic solvents.
Stability:Stable for 1 year from date of purchase as supplied. Solutions in distilled water may be stored at -20°C for up to 1 month.
Safety Information
Hazard Codes T+
Risk Statements 28
Safety Statements 28-36/37-45
RIDADR UN 2811 6.1/PG 2
WGK Germany 3
1-10
HazardClass 6.1
HS Code 29349990
MSDS Information
ProviderLanguage
SigmaAldrich English
BLASTICIDIN S HYDROCHLORIDE Usage And Synthesis
DescriptionBlasticidin S HCl (3513-03-9) is a peptidyl nucleoside antibiotic inhibiting protein synthesis in bacteria and eukaryotes.1?Inhibits translation by trapping deformed tRNA on the ribosome.1?The ABC-type transporter NppA1A2BCD is required for uptake of blasticidin S and other peptidyl nucleoside antibiotics in?Pseudomonas aeruginosa?PA14.2?Selection agent for bis, bsr and bsd transformed cells.3,4
Chemical PropertiesWhite powder
UsesBlasticidin S hydrochloride is a salt of blasticidin S, an amphoteric nucleoside produced by several species of Streptomyces, first reported in the late 1950s. Blasticidin S hydrochloride was originally isolated fby acetone precipitation. For historical reasons only the salt has been routinely available to researchers. Both the salt and free base are freely water soluble. Blasticidin S is an antifungal agent with particularly potent activity against the rice pathogen, Piricularia oryzae, for which it was used commercially for some time in Japan. Blasticidin S inhibits protein synthesis and is active against bacteria, tumour cell lines and nematodes. More recently, blasticidin S has been used as a marker for strain manipulations.
UsesInhibits protein synthesis and induces apoptosis. Used to study protein synthesis at the level of peptide bond formation.
UsesBlasticidin S hydrochloride is used to inhibit protein synthesis in prokaryotic and eukaryotic organisms. It also induces apoptosis.
General DescriptionNucleoside antibiotic that specifically inhibits protein synthesis in both prokaryotes and eukaryotes. Suitable for selection of cells carrying plasmids conferring blasticidin resistance. Blasticidin resistance is conferred by the blasticidin S deaminase gene (bsr) that converts blastisidin S to a nontoxic deaminohydroxy derivative.
storageStore at -20°C
References1) Svidritskiy?et al., (2013),?Blasticidin S inhibits translation by trapping deformed tRNA on the ribosome;?Proc. Natl. Acad. Sci. USA?110?12283 2) Pletzer?et al.?(2015),?The Pseudomonas aeruginosa PA14 ABC Transporter NppA1A2BCD is Required for Uptake of Peptidyl Nucleoside Antibiotics; J. Bacteriol.?197?2217 3) Asada?et al.?(2015),?Transfection of Babesia bovis by Double Selection with WR99210 and Blasticidin-S and Its Application for Functional Analysis of Thioredoxin Peroxidase-1; PLoS One,?10?e0125993 4) Garg and Qadri (2010),?Hemoglobin transforms anti-inflammatory Salmonella typhi virulence polysaccharide into a TLR-2 agonist; J. Immunol.?184?5980
BLASTICIDIN S HYDROCHLORIDE Preparation Products And Raw materials
MALFORMINC Barasertib (AZD1152-HQPA) CHIR-99021 WAY100635 Cefotaxime sodium Clindamycin hydrochloride 5-Azacytidine Ketanserin Geneticin PHLEOMYCIN Hygromycin B H-BETA-ALA-BETA-ALA-OH Demethylblasticidin S BLASTICIDIN S HYDROCHLORIDE,BLASTICIDIN S, HYDROCHLORIDE, STREPTOMYCES GRISEOCHROMOGENES BLASTICIDIN S (S)-2-AMINO-BUT-3-EN-1-OL HYDROCHLORIDE L-ALLOISOTHREONINE HCL BLASTICIDIN S HYDROCHLORIDE

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