Clorsulon

Clorsulon Basic information
Product Name:Clorsulon
Synonyms:4-amino-6-(trichloroethenyl)-3-benzenedisulfonamide;curatrem;keluosuolong;l631529;4-AMINO-6-(TRICHLORO-ETHENYL)-1,3-BENZENEDISULFONAMIDE;4-AMINO-6-TRICHLOROVINYL-1,3-BENZENEDISULFONAMIDE;4-AMINO-6-(TRICHLOROVINYL)-M-BENZENEDISULFONAMIDE;1,3-Benzenedisulfonamide, 4-amino-6-(trichloroethenyl)-
CAS:60200-06-8
MF:C8H8Cl3N3O4S2
MW:380.66
EINECS:262-100-2
Product Categories:ZOMAX;Amines;Aromatics;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
Mol File:60200-06-8.mol
Clorsulon Structure
Clorsulon Chemical Properties
Melting point 194-203°C
Boiling point 651.7±65.0 °C(Predicted)
density 1.800±0.06 g/cm3(Predicted)
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO (Slightly), Methanol (Slightly)
pka9.16±0.60(Predicted)
form neat
color White
CAS DataBase Reference60200-06-8(CAS DataBase Reference)
Safety Information
Safety Statements 24/25
WGK Germany 2
RTECS CZ9090000
HS Code 29350090
ToxicityLD50 in mice (mg/kg): 761 i.p.; >10,000 orally (Ostlind)
MSDS Information
Clorsulon Usage And Synthesis
DescriptionClorsulon is a sulfonamide antiparasitic agent. It induces swelling and blebbing and reduces motility of F. hepatica mature flukes when used at a concentration of 10 μg/ml. In vivo, clorsulon (3.5-15 mg/kg) reduces the number of flukes in a goat model of F. hepatica infection. It completely eradicates naturally acquired F. hepatica adult flukes in sheep and cattle when administered at a dose of 7 mg/kg. Formulations containing clorsulon have been used in the treatment of liver flukes in sheep and cattle.
Chemical PropertiesCrystalline Solid
Usesanalgesic, antiinflammatory
UsesA benzenedisulfonamide derivative with fasciolicidal activity. Anthelmintic (Trematodes).
DefinitionChEBI: 4-amino-6-(1,2,2-trichloroethenyl)benzene-1,3-disulfonamide is a sulfonamide and a member of benzenes.
Brand nameCuratrem [Veterinary] (Merial).
Veterinary Drugs and TreatmentsClorsulon is approved for use in the treatment of immature and adult forms of Fasciola hepatica (Liver fluke) in cattle. It is not effective against immature flukes less than 8 weeks old. It also has activity against Fasciola gigantica. Although not approved, the drug has been used in practice in various other species (e.g., sheep, llamas). It has activity against F. magna in sheep, but is not completely effective in eradicating the organism after a single dose, thus severely limiting its clinical usefulness against this parasite. Clorsulon is also not effective against the rumen fluke (Paramphistomum).
(1,2-DICHLOROVINYL)BENZENE 1,2-DICHLOROPROPENE 3-Aminobenzenesulfonamide BETA-CHLOROSTYRENE 1,1,2-TRICHLOROPROPENE Benzenesulfonamide ALTRENOGEST 6-Aminocaproic acid Glycine Trichloroethylene Sulfanilamide 1,1-DICHLOROPROPENE Tris(hydroxymethyl)aminomethane Clorsulon AMINO ACIDS P-SULFONAMIDO STYRENE 3-Aminophenol 2-Aminobenzenesulfonamide

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