4-Hydroxy-D-(-)-2-phenylglycine

4-Hydroxy-D-(-)-2-phenylglycine Basic information
Product Name:4-Hydroxy-D-(-)-2-phenylglycine
Synonyms:4-HYDROXY-D-PHENYLGLYCINE;(R)-(-)-AMINO(4-HYDROXYPHENYL)ACETIC ACID;(R)-AMINO-(4-HYDROXY-PHENYL)-ACETIC ACID;(r)-alpha-amino-4-hydroxybenzeneacetic acid;(R)-ALPHA-AMINO-4-HYDROXYPHENYLACETIC ACID;(R)-4-HYDROXYPHENYLGLYCINE;(R)-(-)-2-(4-HYDROXYPHENYL)GLYCINE;D-(-)-2-(4-HYDROXYPHENYL)GLYCINE
CAS:22818-40-2
MF:C8H9NO3
MW:167.16
EINECS:245-247-7
Product Categories:Antidote / Antibiotic / Antimicrobial;Miscellaneous Biochemicals;Amino ACIDS SERIES;Cephalosporins;Peptide Synthesis;Phenylglycine Derivatives;Pharmaceutical Intermediates;Unnatural Amino Acid Derivatives;Odevixibat;22818-40-2
Mol File:22818-40-2.mol
4-Hydroxy-D-(-)-2-phenylglycine Structure
4-Hydroxy-D-(-)-2-phenylglycine Chemical Properties
Melting point 240 °C (dec.)(lit.)
alpha -156 º (c=1, 1 N HCl)
Boiling point 295.73°C (rough estimate)
density 1.396
vapor pressure 0Pa at 25℃
refractive index -158 ° (C=1, 1mol/L HCl)
storage temp. 2-8°C
solubility 5g/l
pka2.15±0.10(Predicted)
form Liquid
color Clear colorless to yellow
optical activity[α]23/D 158±3°, c = 1 in 1 M HCl
Water Solubility 5 g/L (20 ºC)
BRN 2210998
LogP-2.25
CAS DataBase Reference22818-40-2(CAS DataBase Reference)
EPA Substance Registry SystemBenzeneacetic acid, .alpha.-amino-4-hydroxy-, (.alpha.R)- (22818-40-2)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26-36-24/25
WGK Germany 3
TSCA Yes
HS Code 29225000
MSDS Information
ProviderLanguage
(R)-alpha-Amino-4-hydroxybenzeneacetic acid English
ACROS English
SigmaAldrich English
ALFA English
4-Hydroxy-D-(-)-2-phenylglycine Usage And Synthesis
Chemical Propertiesoff-white powder
Uses4-Hydroxy-D-(-)-2-phenylglycine is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
Uses4-Hydroxy-D-(-)-2-phenylglycine (Cefadroxil EP Impurity A(Amoxicillin EP Impurity A)) is an compound used mainly for the synthetic preparation of β-lactam antibiotics.
DefinitionChEBI: The D-enantiomer of 4-hydroxyphenylglycine. A non-proteinogenic amino acid found in Herpetosiphon aurantiacus.
Flammability and ExplosibilityNonflammable
Purification MethodsCrystallise it from water and dry it in vacuo. [Beilstein 14 I 659.]
Hydroxyphenyl METHYL 2-AMINO-2-(4-HYDROXYPHENYL)ACETATE Methylparaben Betaine DL-P-Hydroxyphenylglycine 4-Hydroxybenzoic acid D-4-Hydroxyphenylglycine Methyl ester hydrochloride L-(+)-alpha-4-hydroxyphenylglycine,L-4-HYDROXYPHENYLGLYCINE,L-(+)-A-4-HYDROXYPHENYLGLYCINE,L-(+)-P-HYDROXYPHENYLGLYCINE parahydroxy phenylglycine dane salt Fmoc-D-4-Hydroxyphenylglycine GlycineMax 6-Aminocaproic acid Glycine 4-Hydroxyphenylacetic acid 4-Aminophenylacetic acid Anilinoacetic acid CHLOROPHOSPHONAZO III D-2-Phenylglycine

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