L-Hydroxyproline

L-Hydroxyproline Basic information
Product Name:L-Hydroxyproline
Synonyms:H-HYP-OH;H-HYP-OH (TRANS);H-L-HYDROXYPROLINE;H-L-HYP-OH;H-TRANS-HYP-OH;HYDROXYPROLINE;HYDROXY-L-PROLINE;HYDROXY-L-PROLINE, TRANS-4-
CAS:51-35-4
MF:C5H9NO3
MW:131.13
EINECS:200-091-9
Product Categories:Amino Acids;Pyrrole&Pyrrolidine&Pyrroline;Hydroxyproline [Hyp];Unusual Amino Acids;Biochemistry;Biological-modified Amino Acids;Nitrogen cyclic compounds;PHARMACEUTICALS;Amino Acids;L-Amino Acids;Amino Acids & Derivatives;Chiral Reagents;Heterocycles;bc0001;51-35-4
Mol File:51-35-4.mol
L-Hydroxyproline Structure
L-Hydroxyproline Chemical Properties
Melting point 273 °C (dec.)(lit.)
alpha -75.5 º (c=5, H2O)
Boiling point 242.42°C (rough estimate)
density 1.3121 (rough estimate)
vapor density 4.5 (vs air)
refractive index -75.5 ° (C=4, H2O)
storage temp. Store below +30°C.
solubility H2O: 50 mg/mL
form Crystals or Crystalline Powder
pka1.82, 9.66(at 25℃)
color White
PH5.5-6.5 (50g/l, H2O, 20℃)
OdorOdorless
optical activity[α]25/D 75.6°, c = 1 in H2O
Water Solubility 357.8 g/L (20 º C)
Merck 14,4840
BRN 471933
InChIKeyPMMYEEVYMWASQN-DMTCNVIQSA-N
LogP-0.350 (est)
CAS DataBase Reference51-35-4(CAS DataBase Reference)
NIST Chemistry ReferenceHydroxyproline(51-35-4)
EPA Substance Registry Systemtrans-4-Hydroxy-L-proline (51-35-4)
Safety Information
Hazard Codes Xi,Xn
Risk Statements 36/37/38-22
Safety Statements 24/25-36/37/39-27-26
WGK Germany 3
RTECS TW3586500
TSCA Yes
HazardClass IRRITANT
HS Code 29339990
MSDS Information
ProviderLanguage
(2S,4R)-(-)-4-Hydroxy-2-pyrrolinecarboxylic acid English
SigmaAldrich English
ACROS English
ALFA English
L-Hydroxyproline Usage And Synthesis
DescriptionA non-essential amino acid. Can be isolated from gelatin. Hydroxyproline has not been reported as added to food in any of the NAS surveys.
Chemical PropertiesWhite crystalline powder
UsesA natural constituent of animal structural proteins such as collagen and elastin. Several microorganisms producing proline trans-4- and cis-3-hydroxylase were discovered and these enzymes were applied to the industrial production of trans-4- and cis-3-hydroxy-L-proline.
UsesA versatile reagent for the synthesis of neuroexcitatory kainoids and antifungal echinocandins.
Useshydroxyproline is a skin-conditioning amino acid. It is a component of collagen.
DefinitionChEBI: An optically active form of 4-hydroxyproline having L-trans-configuration.
Production MethodsIn the past L-Hydroxyproline was isolated by hydrolysis of animal collagen, e. g. gelatine or collagen, of which it is a major constituent. L-Hydroxyproline is an unnatural amino acid which is made in the body by hydroxylation of L-Proline. The presence of L-Hydroxyproline and proline are key to maintaining the stability of the tight collagen helix.
Today L-Hydroxyproline is manufactured by bio-catalysed hydroxylation of proline in bacteria. Together with its other isomers, L-Hydroxyproline is also used as an inter mediate for a range of pharmaceutical active ingredients.
Produced by hydroxylation of L-proline after protein synthesis. It is contained rich in collagen and elastin. Known to stabilization of triple-helix structure of collagen. Widely used as an intermediate for medicines.

General DescriptionPharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards
Biochem/physiol ActionsTrans-4-Hydroxy-L-proline is used in the organic synthesis of depsilairdin analogues, noncompetitive peptidomimetic inhibitors of multidrug resistance P-glycoprotein and 3-guaninyl-5-hydroxymethyl-2-pyrrolidinone (4) or 3-adeninyl-5-hydroxymethyl-2-pyrrolidinone (5) nucleoside analogues.
Purification MethodsCrystallise it from MeOH/EtOH (1:1). Separation from normal allo-isomer can be achieved by crystallisation of the copper salts [see Levine Biochemical Preparations 8 114 1961]. Separation from proline is achieved via the crystalline picrate, CdCl2, or acid ammonium rhodanate salts [see Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p 2182 1961, Kapfhammer & Mohn Z Physiol Chem 306 76 1956]. [Beilstein 22/5 V 7.]
trans-4-Hydroxy-D-proline H-HYP-OET HCL D-Proline N-Acetyl-L-Hydroxyproline N-Cbz-Hydroxy-L-proline cis-4-Hydroxy-D-proline Z-HYP-OME Boc-Hyp-OH L-Proline cis-4-Hydroxy-L-proline BOC-HYP-OBZL Fmoc-Hyp(tBu)-OH trans,trans-2,4-Undecadienal N-2-4-DNP-HYDROXY-L-PROLINE CRYSTALLINE L-Hydroxyproline BOC-HYP-OH DCHA L-PROLINE-(4-3H(N)) CHLOROPHOSPHONAZO III

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