Cyclopropanecarboxylic acid

Cyclopropanecarboxylic acid Basic information

Product Name:	Cyclopropanecarboxylic acid
Synonyms:	Carboxycyclopropane;Cyclopropionic acid;CYCLOPROPYLMETHANOIC ACID;CYCLOPROPYL CARBOXYLIC ACID;CYCLOPROPANE CARBOYLIC ACID;CYCLOPROPANECARBOXYLIC ACID;CPC-ACID;RARECHEM AL BO 0005
CAS:	1759-53-1
MF:	C4H6O2
MW:	86.09
EINECS:	217-162-5
Product Categories:	Cyclopropanes;Simple 3-Membered Ring Compounds;Pharmaceutical Intermediates;Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;bc0001
Mol File:	1759-53-1.mol

Cyclopropanecarboxylic acid Chemical Properties

Melting point	14-17 °C (lit.)
Boiling point	182-184 °C (lit.)
density	1.081 g/mL at 25 °C (lit.)
refractive index	n20/D 1.438(lit.)
Fp	161 °F
storage temp.	2-8°C
solubility	soluble in Chloroform, Ethyl Acetate
pka	4.83(at 25℃)
form	Liquid
color	Clear colorless to light yellow
PH	3 (10g/l, H2O, 22℃)
BRN	969839
InChIKey	YMGUBTXCNDTFJI-UHFFFAOYSA-N
LogP	0.630
CAS DataBase Reference	1759-53-1(CAS DataBase Reference)
NIST Chemistry Reference	Cyclopropanecarboxylic acid(1759-53-1)
EPA Substance Registry System	Cyclopropanecarboxylic acid (1759-53-1)

Safety Information

Hazard Codes	C,Xi
Risk Statements	34-22
Safety Statements	26-36/37/39-45-27
RIDADR	UN 3265 8/PG 2
WGK Germany	3
RTECS	GZ1100000
Hazard Note	Irritant/Corrosive
TSCA	Yes
HazardClass	8
PackingGroup	II
HS Code	29162000
Toxicity	mouse,LD50,intraperitoneal,172mg/kg (172mg/kg),Journal of Pharmacy and Pharmacology. Vol. 21, Pg. 85, 1969.

MSDS Information

Provider	Language
Trimethylenecarboxylic acid	English
SigmaAldrich	English
ACROS	English
ALFA	English

Cyclopropanecarboxylic acid Usage And Synthesis

Description	Cyclopropanecarboxylic acid is a kind of organic acid. It is a clear liquid used as an intermediate for agrochemicals, pharmaceuticals, and other organic synthesis for the applications of electronics, chemicals, polymer additives, coatings, adhesives, surfactants, and other applications¹. Moreover, its derivatives of are used against parasites in plants and animals. For example, the alkynyl esters of cyclopropane-carboxylic acid are used as pesticides. Similarly, cyclopropane carboxylic acid esters containing a polyhalogenated substituent are used as fungicides. The ethyl derivative is reagent used in the addition of cyclopropane and can act as annulation reagent for the conversion of aromatics to 2-methylindanones under Friedel-Crafts conditions².
Uses	Cyclopropanecarboxylic acid is a monocarboxylic acid and a member of cyclopropanes. It is a conjugate acid of a cyclopropanecarboxylate.
Chemical Properties	clear colourless to light yellow liquid
Uses	Cyclopropanecarboxylic Acid is used as a reagent in the synthesis of substituted 4-(thiophen-2-ylmethyl)-2H-phthalazin-1-ones as potent PARP-1 inhibitors. Also used as a reagent in the synthesis of 2-alkyloxazoles as potent and selective PI4KIIIb inhibitors demonstrating inhibition of HCV replication.
Definition	ChEBI: Cyclopropanecarboxylic acid is a monocarboxylic acid and a member of cyclopropanes. It is a conjugate acid of a cyclopropanecarboxylate.
Preparation	Cyclopropanecarboxylic acid has been prepared by the hydrolysis of cyclopropyl cyanide, although it is unnecessary to isolate the nitrile; by heating cyclopropanedicarboxylic acid; and by the action of alkali on ethyl γ-chlorobutyrate.7 The last two methods do not appear to be of practical importance. The oxidation of cyclopropyl methyl ketone with sodium hypobromite is reported to be an excellent preparative method for this acid. Org. Synth. 1944, 24, 36 DOI: 10.15227/orgsyn.024.0036

Cyclopropanecarboxylic acid Preparation Products And Raw materials

Raw materials

Zinc chloride-->Gamma Butyrolactone-->4-Chlorobutyronitrile-->4-Chlorobutyryl chloride-->Butyl butyrate-->Methyl 4-chlorobutyrate

Preparation Products

1-AMINO-CYCLOPROPANEMETHANOL-->Permethrin-->Cilastatin-->5-CYCLOPROPYL-2H-PYRAZOL-3-YLAMINE-->Deltamethrin-->(1R-cis)-3-(2,2-dibromoethenyl)-2,2-dimethylcyclopropane carboxylic acid-->CYCLOPROTHRIN-->(Bromomethyl)cyclopropane-->3-(1，2，2，2-tetrabromoethyl)-2，2-dimethyl cyclo-propane carboxylic acid-->Ethyl 2,2,3,3-tetramethylcyclopropane-carboxylate-->Cyclopropanecarbonyl Chloride-->Methyl cyclopropane carboxylate-->Cyclopropyl 4-methoxyphenyl ketone-->Ethyl 2,4-dibromobutyrate-->N-METHOXY-N-METHYLCYCLOPROPANECARBOXAMIDE

Methyl cyclopropane carboxylate 1-Phenyl-1-cyclopropanecarboxylic acid Propiconazole Ciprofloxacin hydrochloride DIETHYL 1,2-CYCLOPROPANEDICARBOXYLATE Cyclopropyl methyl ketone Cyclopropyl methoxylamine Ascoric Acid ETHYL 1-METHYLCYCLOPROPANE-1-CARBOXYLATE Cyclopropanecarboxylic acid, 1-methyl- Stearic acid Cyclopropanecarboxylic acid, 2-formyl-, ethyl ester Cyclopropanecarboxylic acid, 2-methyl- Cyclopentanecarboxylic acid Ethyl cyclopropanecarboxylate Cyclopropanecarboxylic acid Cyclopropane-1-carboximidamide hydrochloride Diethyl 1,1-cyclopropanedicarboxylate

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Cyclopropanecarboxylic acid

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