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| | N-Benzyl-4-piperidone Basic information |
| | N-Benzyl-4-piperidone Chemical Properties |
| Boiling point | 134 °C7 mm Hg(lit.) | | density | 1.021 g/mL at 25 °C(lit.) | | vapor pressure | 0.079-0.15Pa at 20-25℃ | | refractive index | n20/D 1.541(lit.) | | Fp | >230 °F | | storage temp. | 2-8°C | | solubility | 12g/l | | pka | 7.07±0.20(Predicted) | | form | Oily Liquid | | color | Clear colorless to straw | | Specific Gravity | 1.021 | | Water Solubility | 12 g/L (20 ºC) | | BRN | 128556 | | LogP | 2.1 at 20℃ and pH9 | | CAS DataBase Reference | 3612-20-2(CAS DataBase Reference) | | NIST Chemistry Reference | 4-Piperidinone, 1-(phenylmethyl)-(3612-20-2) |
| | N-Benzyl-4-piperidone Usage And Synthesis |
| Chemical Properties | Clear colorless to straw coloured oily liquid | | Uses | A substituted piperidine as pesticide | | Uses | 1-Benzyl-4-piperidone is a pharmaceutical intermediate, it is used in penfluridol synthesis of bulk drugs. | | Purification Methods | If the physical properties show contamination, then dissolve it in the minimum volume of H2O, made strongly alkaline with aqueous KOH, extract it with toluene several times, dry the extract with K2CO3, filter, evaporate and distil the residue at high vacuum using a bath temperature of 160-190o, and redistil it. [Brookes & Walker J Chem Soc 3173 1957, Bolyard J Am Chem Soc 52 1030 1930.] The hydrochloride has m 159-161o (from Me2CO/Et2O), and the picrate has m 174-182o (from Me2CO/Et2O). [Grob & Brenneisen Helv Chim Acta 41 1184 1958, Beilstein 21/6 V 424.] |
| | N-Benzyl-4-piperidone Preparation Products And Raw materials |
| Raw materials | Benzylamine-->Methyl propionate-->4,4-Piperidinediol hydrochloride | | Preparation Products | 4,5,6,7-TETRAHYDRO-2-METHYLFURO[3,2-C]PYRIDINE-->1-BENZYL-4-HYDROXY-4-(3-TRIFLUOROTOLYL)PIPERIDINOL-->1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4R)-(9CI)-->1H-Azepine-4-carboxylicacid,hexahydro-,methylester,(4S)-(9CI)-->4-(1-Pyrrolidinyl)piperidine-->1-Benzyl-4-hydroxypiperidine-->(1-BENZYLPIPERIDIN-4-YLIDENE)ACETIC ACID ETHYL ESTER-->1-BOC-4-HYDROXY-4-(HYDROXYMETHYL)-PIPERIDINE-->4-(3-Trifuoromethyl)phenyl-4-piperidinol-->N-Boc-2-piperidone-->2-Oxa-8-azaspiro[4.5]decane-->Methyl 1-benzyl-4-hydroxypiperidine-4-carboxylate-->4-(2-Aminoethyl)-1-benzylpiperidine-->4-(4-FLUORO-PHENYL)-PIPERIDIN-4-OL HYDROCHLORIDE-->4-METHYLENEPIPERIDINE-->TERT-BUTYL 1-OXA-4,9-DIAZASPIRO[5.5]UNDECANE-4-CARBOXYLATE |
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