3-Methyl-2-cyclohexen-1-one

3-Methyl-2-cyclohexen-1-one Basic information
Product Name:3-Methyl-2-cyclohexen-1-one
Synonyms:3-METHYL-2-CYCLOHEXEN-1-ONE;Methyl-2-cyclohexen;3-Methyl-2-cyclohexenone 98%;FEMA 3360;TIMTEC-BB SBB007736;3-METHYL-2-CYCLOHEXEN-1-ONE 98+%;3-Methyl-2-cyclohexen-1-one, 98% 10GR;ohexenone
CAS:1193-18-6
MF:C7H10O
MW:110.15
EINECS:214-769-7
Product Categories:Alphabetical Listings;Flavors and Fragrances;M-N;C7 to C8;Carbonyl Compounds;Ketones;insect pheromone;Pyridines ,Halogenated Heterocycles
Mol File:1193-18-6.mol
3-Methyl-2-cyclohexen-1-one Structure
3-Methyl-2-cyclohexen-1-one Chemical Properties
Melting point -21°C
Boiling point 199-200 °C(lit.)
density 0.971 g/mL at 25 °C(lit.)
FEMA 3360 | 3-METHYL-2-CYCLOHEXEN-1-ONE
refractive index n20/D 1.494(lit.)
Fp 155 °F
storage temp. Inert atmosphere,Room Temperature
form Liquid
Specific Gravity0.971
color Clear very slightly yellow to brown
Odorat 1.00 % in dipropylene glycol. nut caramel phenolic cherry
Odor Typenutty
Water Solubility insoluble
JECFA Number1107
BRN 1560601
LogP1.04
CAS DataBase Reference1193-18-6(CAS DataBase Reference)
NIST Chemistry Reference2-Cyclohexen-1-one, 3-methyl-(1193-18-6)
EPA Substance Registry System3-Methyl-2-cyclohexen-1-one (1193-18-6)
Safety Information
Hazard Codes Xn
Risk Statements 22-36-20/21/22
Safety Statements 36/37/39-26-24/25
WGK Germany 3
RTECS GW7340000
10
TSCA Yes
HS Code 29142990
MSDS Information
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3-Methyl-2-cyclohexen-1-one English
SigmaAldrich English
ACROS English
ALFA English
3-Methyl-2-cyclohexen-1-one Usage And Synthesis
DescriptionMay be prepared by acid hydrolysis and decarboxylation of the corresponding 4-carbetoxy derivative; by oxidation of 1-methylcyclohex-l-ene with chromium trioxide in acetic acid; by cyclization of 3-carbetoxy-6-chlorohept-5-en-2-one with sulfuric acid.
Chemical PropertiesCLEAR VERY SLIGHTLY YELLOW TO BROWN LIQUID
Chemical Properties3-Methyl-2-cyclohexen-1-one is a nonaromatic cyclic ketone with a medicinal, phenolic, mild cherry aroma
OccurrenceReported found in oil of Mentha pulegium, cocoa, coffee, filbert, sweet corn, dried bonito, katsuobushi, wild rice and clam. Also produced by some animals in vivo
Uses3-Methyl-2-cyclohexen-1-one was used in the synthesis of 19-nor-1α, 25-dihydroxyvitamin D(3) derivatives. It was also used in sex pheromone of the Douglas-fir beetle. Used in nut flavor.
Uses3-Methyl-2-cyclohexenone is an insect sex pheromone of the Douglas-fir beetle. It can be used as a starting material:
  • In the total synthesis of (?)-ar-tenuifolene, a naturally occurring aromatic sesquiterpene.
  • To synthesize an organic building block 2-trimethylsilyl-3-methyl-cyclohexenone.
  • In the total synthesis of natural diterpenoids (+)-taiwaniaquinone H and (+)-dichroanone.

DefinitionChEBI: 3-Methyl-2-cyclohexen-1-one is a cyclic olefin.
PreparationBy acid hydrolysis and decarboxylation of the corresponding 4-carbetoxy derivative; by oxidation of 1-methylcyclohex-1-ene with chromium trioxide in acetic acid; by cyclization of 3-carbetoxy-6-chlorohept-5-en-2-one with sulfuric acid.
Aroma threshold valuesAroma characteristics at 2.0%: sweet, nutty, phenolic, walnut, fruity, almond and benzoin
Taste threshold valuesTaste characteristics at 50 ppm: nutty, musty, phenolic and woody with grain-like nuances.
Synthesis Reference(s)Journal of the American Chemical Society, 101, p. 494, 1979 DOI: 10.1021/ja00496a044
The Journal of Organic Chemistry, 42, p. 1349, 1977 DOI: 10.1021/jo00428a017
Tetrahedron Letters, 17, p. 3, 1976
6-[3-(Acetyloxy)-1-methylpropyl]-3-methyl-2-cyclohexen-1-one WIELAND-MIESCHER KETONE Methyl 5-ANDROSTENEDIOL Adrenosterone 4-CARBETHOXY-2-ETHYL-3-METHYL-2-CYCLOHEXEN-1-ONE 5-PHENYL-3-(PHENYLSULFANYL)-2-[(PHENYLSULFONYL)METHYL]-2-CYCLOHEXEN-1-ONE Tabanone 4-CARBETHOXY-3-METHYL-2-CYCLOHEXEN-1-ONE CORTISONE 3,5-Dimethyl-2-cyclohexen-1-one 16-Dehydroprogesterone 19-HYDROXY-4-ANDROSTENE-3,17-DIONE (S)-6β-[(S)-1-Hydroxy-1,5-dimethyl-4-hexenyl]-3-methyl-2-cyclohexen-1-one 2-Methyl-5-cyclohexen-1-one,6-Methyl-2-cyclohexen-1-one Cortisone acetate 11ALPHA-HYDROXYPROGESTERONE 3-METHYL-3-CYCLOHEXEN-1-ONE

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