Fmoc-Ile-OH

Fmoc-Ile-OH Basic information

Product Name:	Fmoc-Ile-OH
Synonyms:	Fmoc-Ile-OH >=98.0% (T);N-FMOC-L-ISOLEUCINE;N-FMOC-ILE-OH;Fmoc-(2S,3S)-2-amino-3-methylpentanoic acid;Fmoc-L-isoleucine≥ 99% (HPLC);Fmoc-lle-OH;L-Isoleucine, FMOC protected;N-FMOC-ILE-OH ( N-FMOC-L-ISOLEUCINE)
CAS:	71989-23-6
MF:	C21H23NO4
MW:	353.41
EINECS:	276-255-9
Product Categories:	Isoleucine [Ile, I];Fmoc-Amino Acids and Derivatives;Amino Acids (N-Protected);Biochemistry;Fmoc-Amino Acids;Fmoc-Amino acid series;Protected Amino Acids;Fluorenes, Flurenones;AMINOACIDS DERIVATIVES;Amino Acids
Mol File:	71989-23-6.mol

Fmoc-Ile-OH Chemical Properties

Melting point	145-147 °C(lit.)
alpha	-12 º (c=1,DMF)
Boiling point	486.83°C (rough estimate)
density	1.2107 (rough estimate)
refractive index	-12 ° (C=1, DMF)
storage temp.	2-8°C
solubility	Soluble in methanol (very faint turbidity).
pka	3.92±0.22(Predicted)
form	Fine Crystalline Powder
color	White
optical activity	[α]20/D 12±1°, c = 1% in DMF
BRN	4716717
InChI	InChI=1S/C21H23NO4/c1-3-13(2)19(20(23)24)22-21(25)26-12-18-16-10-6-4-8-14(16)15-9-5-7-11-17(15)18/h4-11,13,18-19H,3,12H2,1-2H3,(H,22,25)(H,23,24)/t13-,19-/m0/s1
InChIKey	QXVFEIPAZSXRGM-DJJJIMSYSA-N
SMILES	C(O)(=O)[C@H]([C@@H](C)CC)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
CAS DataBase Reference	71989-23-6(CAS DataBase Reference)

Safety Information

Hazard Codes	Xi
Risk Statements	36/37/38
Safety Statements	22-24/25-36/37/39-27-26
WGK Germany	3
Hazard Note	Irritant
HS Code	2924 29 70

MSDS Information

Provider	Language
2-{[(9H-Fluoren-9-ylmethoxy)carbonyl]amino}-3-methylpentanoic acid	English
ACROS	English
SigmaAldrich	English
ALFA	English

Fmoc-Ile-OH Usage And Synthesis

Description	Fmoc-Ile-OH is an isoleucine derivative. It is white fine crystalline powder and belong to Fmoc materials. Fmoc-Leu-OH forms flower-like morphology at both low and high concentration under room temperature which changes to small tube-like structure on heating^[1].
Chemical Properties	white fine crystalline powder
Uses	N-Fmoc-L-isoleucine is an unnatural amino acid used for peptidomimetics. It is also used as a pharmaceutical intermediate.
General Description	The product number for this product was previously 04-12-1024. To obtain a certificate of analysis (CoA) of a lot that begins with the letter “A”, please select the option in the right hand menu “Request a COA for Lot#s starting with A”.
References	[1] N. Gour, B. Koshti, S. Naskar, V. Kshtriya, H. Narode, Self-assembled Structures Formed by Fmoc modified aliphatic amino acids, ChemRxiv, 2021.

Fmoc-Ile-OH Preparation Products And Raw materials

Raw materials	9-FLUORENYLMETHYL PENTAFLUOROPHENYL CARBONATE-->L-Isoleucine hydrochloride-->(9H-fluoren-9-yl)methyl 2,5-dioxopyrrolidine-1-carboxylate-->N-(9-Fluorenylmethoxycarbonyloxy)succinimide-->1-Hydroxybenzotriazole-->9-Fluorenylmethyl chloroformate-->L-Isoleucine
Preparation Products	4-Methylphenethylamine-->INDOLICIDIN-->ANGIOTENSIN I, HUMAN-->MELITTIN-->ANGIOTENSIN II, HUMAN-->Fmoc-L-beta-homoisoleucine

1,1'-Carbonyldiimidazole (2R,3R)-2-Amino-3-methylpentanoic acid Fmoc-N-methyl-L-isoleucine N-ALPHA-FMOC-L-ISOLEUCINE PENTAFLUOROPHENYL ESTER,FMOC-L-ISOLEUCINE PENTAFLUOROPHENYL ESTER FMOC-L-ISOLEUCINE N-HYDROXYSUCCINIMIDE ESTER,FMOC-L-ISOLEUCINE HYDROXYSUCCINIMIDE ESTER,FMOC-L-ISOLEUCINE HYDROXYSUCCINIMIDESTER N-alpha-FMOC-Nepsilon-BOC-L-Lysine L-Isoleucine PYRAZOPHOS Fmoc-Aib-OH fmoc-L-isoleucine N-carboxy anhydride ALTRENOGEST Isoleucine FMOC-CHG-OH FMOC-L-ISOLEUCINE-15N AMINO ACIDS L-Leucine Fmoc N-CARBOBENZOXY-DL-LEUCINE

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