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| | N-azidoacetylmannosamine-tetraacylated Basic information |
| Product Name: | N-azidoacetylmannosamine-tetraacylated | | Synonyms: | N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz);N-Azidoacetylmannosamine-tetraacylated 95%;N-Azidoacetylmannosamine-tetraacylated;Ac4ManNAz,N-Azidoacetylmannosamine-tetraacylated;1,3,4,6-Tetra-O-acetyl-N-azidoacetylmannosamine;(3S,4R,5S,6R)-6-(Acetoxymethyl)-3-(2-azidoacetamido)tetrahydropyran-2,4,5-triyl Triacetate;2-[(2-Azidoacetyl) amino] -2-deoxy-1,3,4,6- tetra-O-acetyl-D-manno- pyranose;1,3,4,6-Tetra-O-acetyl-N-azidoacetylmannosamine(Ac4ManNAz) | | CAS: | 361154-30-5 | | MF: | C16H22N4O10 | | MW: | 430.37 | | EINECS: | | | Product Categories: | | | Mol File: | 361154-30-5.mol |  |
| | N-azidoacetylmannosamine-tetraacylated Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO:100 mg/mL (232.36 mM; Need ultrasonic | | form | powder or crystals |
| | N-azidoacetylmannosamine-tetraacylated Usage And Synthesis |
| Application | N-Azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an azide-containing metabolic glycoprotein labeling reagent that can be incorporated into the sialic acid biosynthesis pathway. The azide-modified protein can be detected by reaction with alkynes. For example alkynes labeled with a fluorescent probe or a biotin can be used. The acetyl groups increase cell permeability and allow the unnatural sugars to easily pass through the cell membrane. Carboxyesterases remove the acetyl groups once the monosaccharide is in the cell.
| | Description | N-azidoacetylmannosamine-tetraacylated (Ac4ManNAz) is an unnatural azido-containing monosaccharide building block. The azide moiety can be used for modification though chemoselective ligation chemistries including CuAAC, Cu-free click reaction or Staudinger ligation. The acetyl groups increase solubility in many solvents and make handling of this reagent easier. | | Uses | Tetraacylated N-azidoacetylmannosamine is generally used in click chemistry applications in bioconjugate chemistry. | | storage | Store at -20°C |
| | N-azidoacetylmannosamine-tetraacylated Preparation Products And Raw materials |
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