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Sacubitril Impurity 7

Sacubitril Impurity 7 Basic information
Product Name:Sacubitril Impurity 7
Synonyms:(2R,4S)-4-(3-carboxypropanoylamino)-2-methyl-5-(4-phenylphenyl)pentanoic acid;LCZ696-4;Diacid of Sacubitril;LBQ657;Sacubitrilat;LCZ-696 Impurity 1;Sacubitrilat (LBQ-657);Sacubitril Desethyl Impurity
CAS:149709-44-4
MF:C22H25NO5
MW:383.44
EINECS:
Product Categories:
Mol File:149709-44-4.mol
Sacubitril Impurity 7 Structure
Sacubitril Impurity 7 Chemical Properties
Boiling point 705.4±60.0 °C(Predicted)
density 1?+-.0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DMF:30.0(Max Conc. mg/mL);78.24(Max Conc. mM)
DMSO:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:77.0(Max Conc. mg/mL);200.81(Max Conc. mM)
Ethanol:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.3(Max Conc. mM)


form A crystalline solid
pka4.59±0.23(Predicted)
Safety Information
MSDS Information
Sacubitril Impurity 7 Usage And Synthesis
UsesDesethyl Sacubitril is an impurity in the synthesis of Sacubitril (S080895), an antihypertensive drug used in combination with valsartan. The combination drug, valsartan/sacubitril, known during trials as LCZ696 and marketed under the brand name, Entresto, is a treatment for heart failure.
Sacubitril Impurity 7 Preparation Products And Raw materials
Sacubitril Impurity 21 Sacubitril Impurity 22 Sacubitril Impurity 8 Sacubitril Impurity 4 Sacubitril Impurity 23 Sacubitril Impurity 19 Sacubitril Impurity 3 Sildenafil EP Impurity G Sacubitril Impurity 72 Sacubitril Impurity 5 (2S,4S)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Ethyl (2R,4S)-4-([1,1'-biphenyl]-4-ylmethyl)-2-methyl-4-(2,5-dioxopyrrolidin-1-yl)butanoate Sacubitril Impurity 24 HCl ((R)-2-biphenyl-4-yl-1-forMylethyl)carbaMic acid t-butyl ester Sacubitril Impurity 20 Sacubitril Impurity 7 (2R,4R)-5-(Biphenyl-4-yl)-4-[(tert-butoxycarbonyl)amino]-2-methylpentanoic acid Sacubitril Impurity 6
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