3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline

3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Basic information

Product Name:	3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline
Synonyms:	3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline;Benzenamine, 3-(1H-imidazol-1-yl)-5-(trifluoromethyl)-
CAS:	943320-48-7
MF:	C10H8F3N3
MW:	227.19
EINECS:
Product Categories:
Mol File:	943320-48-7.mol

3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Chemical Properties

Boiling point	365.8±42.0 °C(Predicted)
density	1.39±0.1 g/cm3(Predicted)
pka	5.31±0.10(Predicted)

Safety Information

MSDS Information

3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Usage And Synthesis

Uses	3-(1H-Imidazol-1-yl)-5-(trifluoromethyl)-aniline is a reactant used in the synthesis of novel Bcr/Abl inhibitors as anti-cancer drugs. Nilotinib (N465300) impurity, which might be useful in treatment of chronic myelogenous leukemia.

3-(1H-imidazol-1-yl)-5-(trifluoromethyl)aniline Preparation Products And Raw materials

Raw materials

3,5-Diaminobenzotrifluoride-->3-Amino-5-bromobenzotrifluoride-->Imidazole

3-(4-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzamide Nilotinib impurity 3 Nilotinib Impurity 28 3-Amino-4-methylbenzoic acid Nilotinib Impurity 20 Nilotinib Impurity 1 Nilotinib genotoxic impurity 3 Nilotinib Impurity 7 Nilotinib N-Oxide Nilotinib Impurity 10 Methyl 3-amino-4-methylbenzoate Benzenamine, 3-(2-methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)- 4-Methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]benzoic acid 3-(4-Methyl-1H-imidazol-1-yl)-5-(trifluoromethyl)benzonitrile 1H-IMidazole, 4-Methyl-1-[3-nitro-5-(trifluoroMethyl)phenyl]- 3-[(Aminoiminomethyl)amino]-4-methylbenzoic acid ethyl ester mononitrate 3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)benzenaMine 4-Methyl-N-(3-(5-Methyl-1H-iMidazol-1-yl)-5-(trifluoroMethyl)phenyl)-3-((4-(pyridin-3-yl)pyriMidin-2-yl)aMino)benzaMide

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