PPACK, DIHYDROCHLORIDE

PPACK, DIHYDROCHLORIDE Basic information
Product Name:PPACK, DIHYDROCHLORIDE
Synonyms:PPACK, DIHYDROCHLORIDE;PPACK TRIFLUOROACETATE;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE 2HCL;H-D-PHE-PRO-ARG-CHLOROMETHYLKETONE TFA;H-D-PHE-PRO-ARG-CMK 2HCL;PPACK, DiHCl;PPACK DIHYDROCHLORIDE[D-PHE-PRO-ARG-CHLOROMETHYLKETONE, HCL];D-Phe-Pro-Arg-CMK.HCl
CAS:142036-63-3
MF:C21H32Cl2N6O3
MW:487.43
EINECS:
Product Categories:ProteaseInhibitors
Mol File:142036-63-3.mol
PPACK, DIHYDROCHLORIDE Structure
PPACK, DIHYDROCHLORIDE Chemical Properties
storage temp. 0-6°C
solubility ≥49.5 mg/mL in DMSO; ≥32.5 mg/mL in EtOH; ≥37.9 mg/mL in H2O
Safety Information
MSDS Information
PPACK, DIHYDROCHLORIDE Usage And Synthesis
Biological Activityppack dihydrochloride is the dihydrochloride form of its active component ppack (d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone), a potent, selective and irreversible inhibitor of thrombin that inhibits human α-thrombin with inhibition constant kivalue of 0.24 nm. ppack covalently binds to the specific active-site ser of thrombin and cross links with his57 at the binding site forming a tetrahedral ppack-thrombin complex. the complex further binds to and saturates the high-affinity functional thrombin receptors eventually leading to the inhibition of thrombin activation. ppack is currently being investigated as an anti-coagulant to prevent blood coagulation. study results show that ppack is able to dose-dependently inhibit thrombin-induced platelet accumulation.jun t. liu, william paul, michael emerson, carla cicala and clive p. page. thrombin inhibitors and anti-coagulants on thrombin-induced embolization in rabbit cranial vasculature. european journal of pharmacology 264 (1994) 183-190ildiko m. kovach, paul kelley, carol eddy, frank jordan and ahmet baykal. proton bridging in the interactions of thrombin with small inhibitors. biochemistry. 2009; 48(30): 7296-7304martha e. lyon, james s. fine, paul j. henderson and andrew w. lyon. d-phenylalanyl-l-prolyl-l-arginine chloromethyl ketone (ppack): alternative anticoagulant to heparin salts for blood gas and electrolyte specimens. clin. chem. 41/7, 1038-1041 (1995)
PPACK, DIHYDROCHLORIDE Preparation Products And Raw materials
H-ALA-NHME HCL 1-CHLOROBUTANONE H-PRO-NHET HCL 2-Pyrrolidinecarboxamide,N-propyl-,(2S)-(9CI) 2-PYRROLIDINOETHYLAMINE 2HCL CHEMBRDG-BB 4100050 3-Chloropropylamine hydrochloride (S)-2-Aminobutyramide hydrochloride 1-(2-Aminoethyl)pyrrolidine N-[(1-PROPYL-2-PYRROLIDINYL)METHYL]-1-PROPANAMINE PPACK, DIHYDROCHLORIDE DTYR-PRO-ARG-CHLOROMETHYLKETONE N1,N1-DIETHYLETHANE-1,2-DIAMINE DIHYDROCHLORIDE 2-Pyrrolidinecarboxamide,(S)- 1-AMINO-4-GUANIDINOBUTANE 2HCL (2R)-2-Aminopropanamide hydrochloride (S)-(+)-2-(AMINOMETHYL)PYRROLIDINE (R)-(-)-2-AMINOBUTANAMIDE HYDROCHLORIDE, 97%

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