Diethylcarbamyl chloride

Diethylcarbamyl chloride Basic information
Product Name:Diethylcarbamyl chloride
Synonyms:Carbamicchloride,diethyl-;Carbamidoyl chloride, diethyl-;Carbamoyl chloride, diethyl-;Diethylamid kyseliny chlormravenci;n,n-diethylcarbamoylchloride;N,N-Diethylchloroformamide;CHLOROFORMIC ACID DIETHYLAMIDE;DIETHYLAMINO FORMYL CHLORIDE
CAS:88-10-8
MF:C5H10ClNO
MW:135.59
EINECS:201-798-5
Product Categories:Acid Halides;Building Blocks;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks;Pharmaceutical Intermediates
Mol File:88-10-8.mol
Diethylcarbamyl chloride Structure
Diethylcarbamyl chloride Chemical Properties
Melting point −32 °C(lit.)
Boiling point 117-123 °C133 mm Hg(lit.)
density 1.07 g/mL at 25 °C(lit.)
refractive index n20/D 1.451(lit.)
Fp 167 °F
storage temp. Inert atmosphere,2-8°C
solubility Chloroform (Soluble), Methanol (Slightly)
pka-1.85±0.70(Predicted)
form Liquid
color Clear
Specific Gravity1.070
Water Solubility HYDROLYSIS
Sensitive Moisture Sensitive
BRN 506687
Stability:Moisture Sensitive
InChIKeyOFCCYDUUBNUJIB-UHFFFAOYSA-N
CAS DataBase Reference88-10-8(CAS DataBase Reference)
NIST Chemistry ReferenceCarbamic chloride, diethyl-(88-10-8)
EPA Substance Registry SystemDiethylcarbamoyl chloride (88-10-8)
Safety Information
Hazard Codes Xn
Risk Statements 20/22-36/37/38-40
Safety Statements 26-36/37
RIDADR UN 3265 8/PG 3
WGK Germany 1
RTECS FD4025000
TSCA Yes
HazardClass 8
PackingGroup II
HS Code 29241990
Hazardous Substances Data88-10-8(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Diethylcarbamoyl chloride English
SigmaAldrich English
ACROS English
ALFA English
Diethylcarbamyl chloride Usage And Synthesis
Chemical Propertiesclear yellow to brownish liquid
UsesIt is used in the production of pharma ingredients. It is a reagent in the synthesis of S-Methyl-N,N-diethylthiocarbamate Sulfoxide, which is an oxygenated metabolite of Disulfiram (Antabuse) that is capable of in vitro inactivation of liver mitochondrial aldehyde dehydrogenase.
Safety ProfileSuspected carcinogen with experimental carcinogenic data. Moderately toxic by intraperitoneal route. Mutation data reported. Reacts with water or steam to produce toxic and corrosive fumes. When heated to decomposition it emits highly toxic fumes of Cl and NOx. See also CARBATMATES and CHLORIDES.
N,N-BIS(2-CHLOROETHYL)BENZENEMETHANAMINE TSTU 1-PYRROLIDINECARBONYL CHLORIDE 4-Methyl-1-piperazinecarbonyl chloride hydrochloride POLY(N-ISOPROPYL ACRYLAMIDE) 1-PIPERIDINECARBONYL CHLORIDE DIBUTYLCARBAMYL CHLORIDE 4-Ethyl-2,3-dioxo-1-piperazine carbonyl chloride N-Acetylsulfanilyl chloride 4-(2-(N-CHLOROCARBONYL-N-ISOPROPYL)AMINOMETHYL-4-NITRO)PHENOXY-1-HYDROXY-N-(2-TETRADECYLOXYPHENYL)-2-NAPHTHALENE CARBOXAMIDE Mepiquat chloride BIS(1-METHYLPROPYL)CARBAMIC CHLORIDE N,N-Bis(2-chloroethyl)carbamoyl chloride Diethylcarbamyl chloride 4-Morpholinecarbonyl chloride 2-Diethylaminoethanethiol 2-​[[(2-​ethylphenyl)​(2-​hydroxyethyl)​amino]​methyl]​-​3,​3-​difluoro-Propanenitrile DIISOPROPYLCARBAMOYL CHLORIDE

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