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Macitentan impurity B

Macitentan impurity B Basic information
Product Name:Macitentan impurity B
Synonyms:Macitentan impurity B;Macitentan impurity D;Macitentan N-Despropyl-N-Ethyl Impurity;Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]-N'-ethyl-;Macitentan N-Despropyl-N-Ethyl Impurity/ Macitentan N-Ethyl Analog;5-(4-bromophenyl)-6-[2-(5-bromopyrimidin-2-yl)oxyethoxy]-N-(ethylsulfamoyl)pyrimidin-4-amine;Macitentan Impurity 04
CAS:441796-13-0
MF:C18H18Br2N6O4S
MW:574.25
EINECS:
Product Categories:
Mol File:441796-13-0.mol
Macitentan impurity B Structure
Macitentan impurity B Chemical Properties
Boiling point 686.7±65.0 °C(Predicted)
density 1.715±0.06 g/cm3(Predicted)
pka6.90±0.50(Predicted)
Safety Information
MSDS Information
Macitentan impurity B Usage And Synthesis
UsesN-Despropyl-N-ethyl Macitentan is an impurity of Macitentan (M105005); a dual orally active and potent endothelin receptor antagonist used for pulmonary arterial hypertension.
Macitentan impurity B Preparation Products And Raw materials
CarbaMic acid, N-[(propylaMino)sulfonyl]-, phenylMethyl ester PropylsulfaMide Macitentan Impurity 13 ACT 080803 Macitentan Impurity 2 2-(4-BROMOPHENYL)-PROPANEDIOIC ACID, 1,3-MDIETHYL ESTER Macitentan Impurity 4 5-(4-Bromophenyl)-4,6-dichloropyrimidine Macitentan impurity A SulfaMide, N-propyl-,(potassiuM salt)(1:1) N-Propylsulfuric diamide-sodium ACT 373898 4(1H)-PyriMidinone, 5-(4-broMophenyl)-6-hydroxy- NA Macitentan Impurity 12 SulfaMide, N-[5-(4-broMophenyl)-6-chloro-4-pyriMidinyl]-N'-propyl- N-Methyl Maprotiline Macitentan IMpurity
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