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| | tert-Butyl 3-(2-hydroxyethoxy)propanoate Basic information |
| Product Name: | tert-Butyl 3-(2-hydroxyethoxy)propanoate | | Synonyms: | tert-Butyl 3-(2-hydroxyethoxy)propanoate;HO-PEG1-CH2CH2COOTBU;Hydroxy-PEG1-t-butyl ester;3-(2-Hydroxyethoxy)propanoic acid 1,1-dimethylethyl ester;3-(2-Hydroxyethoxy)propanoic acid tert-butyl ester;HO-PEG1-t-Butyl ester;OH-PEG1-CH2CH2COOtBu;Hydroxy-PEG1-(CH2)2-Boc | | CAS: | 671802-00-9 | | MF: | C9H18O4 | | MW: | 190.24 | | EINECS: | | | Product Categories: | peg | | Mol File: | 671802-00-9.mol |  |
| | tert-Butyl 3-(2-hydroxyethoxy)propanoate Chemical Properties |
| Boiling point | 274.0±15.0 °C(Predicted) | | density | 1.031±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 14.36±0.10(Predicted) | | form | liquid | | color | Yellowish | | Water Solubility | Water: 100 mg/mL (525.65 mM) |
| | tert-Butyl 3-(2-hydroxyethoxy)propanoate Usage And Synthesis |
| Description | Hydroxy-PEG1-t-butyl ester is a PEG linker containing a hydroxyl group with a t-butyl ester. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The t-butyl protected carboxyl group can be deprotected under acidic conditions. | | Uses | tert-Butyl 3-(2-hydroxyethoxy)propanoate is a reactant in the synthesis of hydrophilic aminooxy linked and multivalent disaccharide cellobiose derivatives for chemoselective aldehyde/ketone conjugation | | Uses | tert-Butyl 3-(2-hydroxyethoxy)propanoate can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and pharmaceutical and chemical production process. | | Synthesis | 
To a solution of anhydrous ethylene glycol (10 g, 161.1 mmol) in anhydrous THF (40 mL) was added sodium metal (62.0 mg, 2.70 mmol) and stirred at room temperature for 2 hours.Add tert-butyl acrylate (6.90, 53.7 mmol) and stir overnight.After quenching with water, the solvent was THF dried under reduced pressure, and extracted with ethyl acetate and water.The organic layer was separated, washed with brine, and dried over Na 2 SO 4.After filtration and evaporation, the residue was purified by silica gel column chromatography (petroleum ether/ethyl acetate = 2:1) to obtain a colorless oil 44 (5.0 g, 26.3 mmol, 49% yield) |
| | tert-Butyl 3-(2-hydroxyethoxy)propanoate Preparation Products And Raw materials |
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