4-(hidroximetil)-5-metil-1,3-dioxol-2-one

4-(hidroximetil)-5-metil-1,3-dioxol-2-one Basic information
Product Name:4-(hidroximetil)-5-metil-1,3-dioxol-2-one
Synonyms:4-(HydroxyMethyl)-5-Methyl-[1,3]dioxol-2-one;1,3-Dioxol-2-one, 4-(hydroxymethyl)-5-methyl-;4-(hidroximetil)-5-metil-1,3-dioxol-2-ona;4-(hydroxymethyl)-5-methyl-l,3-dioxol-2-one;4-(hidroxiMetil)-5-Metil-1,3-dioxol-2-one;DMDO-OH;4-Methyl-5-hydroxyMethyl-2-oxo-1,3-dioxol-4-ene;AZATMint-D
CAS:91526-18-0
MF:C5H6O4
MW:130.1
EINECS:1308068-626-2
Product Categories:
Mol File:91526-18-0.mol
4-(hidroximetil)-5-metil-1,3-dioxol-2-one Structure
4-(hidroximetil)-5-metil-1,3-dioxol-2-one Chemical Properties
Boiling point 214℃
density 1.367
Fp 93℃
storage temp. Inert atmosphere,Store in freezer, under -20°C
solubility Chloroform (Slightly), Methanol (Slightly)
form liquid
pka14.54±0.10(Predicted)
color Pale yellow
InChIInChI=1S/C5H6O4/c1-3-4(2-6)9-5(7)8-3/h6H,2H2,1H3
InChIKeyJEQSUJXHFAXJOW-UHFFFAOYSA-N
SMILESO1C(C)=C(CO)OC1=O
Safety Information
HS Code 2932990090
MSDS Information
4-(hidroximetil)-5-metil-1,3-dioxol-2-one Usage And Synthesis
Description4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is a reagent used in organic synthesis, particularly for the introduction of the non-chiral (oxodioxolenyl)methyl carbamate group to active pharmaceutical ingredients (APIs) to afford the corresponding pro-drug.
Uses4-(Hydroxymethyl)-5-methyl-1,3-dioxol-2-one is used in preparation method of key intermediate of olmesartan medoxomil.
Methyl 2-oxo-3-((2'-(5-oxo-4,5-dihydro-1,2,4-oxadiazol-3-yl)biphenyl-4-yl)Methyl)-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate Azilsartan iMpurity I (Z)-Methyl 3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-2-oxo-2,3-dihydro-1H-benzo[d]iMidazole-4-carboxylate Azilsartan (Z)-2-ethoxy-3-((2'-(N'-hydroxycarbaMiMidoyl)biphenyl-4-yl)Methyl)-3H-benzo[d]iMidazole-4-carboxylic acid Ethyl-3-Amino-2-[(2'-Cyanoiphenyl-4-yl) Methyl]-Amino Benzoate Azilsartan Medoxomil Methyl 3-aMino-2-((2'-carbaMoylbiphenyl-4-yl)MethylaMino)benzoate BENZOIC ACID, 2-[[(2'-CYANO[1,1'-BIPHENYL]-4-YL)METHYL]AMINO]-3-NITRO-METHYL ESTER 2-[Bis[(1,1-diMethylethoxy)carbonyl]aMino]-3-nitrobenzoic Acid Methyl Ester 1-((2'-cyanobiphenyl-4-yl)Methyl)-2-ethoxy-1H-benziMidazole-7-carboxylic acid Azilsartan Impurity

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