ChemicalBook Product Catalog Pharmaceutical intermediates Heterocyclic compound Pyridine compound Nitropyridine 2-Fluoro-5-nitropyridine

2-Fluoro-5-nitropyridine

2-Fluoro-5-nitropyridine Basic information
Product Name:2-Fluoro-5-nitropyridine
Synonyms:2-FLUORO-5-NITROPYRIDINE;6-FLUORO-3-NITROPYRIDINE;2-Fluoro-5-nitropyridine >;uoro-5-nitropyridine;Pyridine, 2-fluoro-5-nitro-;2-Fluoro-5-nitropyridine ISO 9001：2015 REACH
CAS:456-24-6
MF:C5H3FN2O2
MW:142.09
EINECS:207-260-6
Product Categories:Fluorine series;blocks;FluoroCompounds;NitroCompounds;Pyridines;Pyridine;Fluorin-contained pyridine series;Pyridine series;Boronic Acid
Mol File:456-24-6.mol
2-Fluoro-5-nitropyridine Structure
2-Fluoro-5-nitropyridine Chemical Properties
Melting point 142-144 C
Boiling point 86-87℃/7mm lit.
density 4,64g/cm
refractive index 1.5250
storage temp. Inert atmosphere,Room Temperature
form Liquid
pka-4.47±0.10(Predicted)
color Colorless to pale yellow
Water Solubility Slightly soluble in water.
Sensitive Moisture Sensitive
CAS DataBase Reference456-24-6(CAS DataBase Reference)
Safety Information
Hazard Codes Xn
Risk Statements 20/21/22-22
Safety Statements 36
RIDADR UN 1549
HS Code 2933399990
MSDS Information
2-Fluoro-5-nitropyridine Usage And Synthesis
UsesIt is used in the preparation of nitropyridines by nitration of pyridines with nitric acid.
Uses2-Fluoro-5-nitropyridine can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.
SynthesisSynthesis_456-24-6
Synthesis of 5-amino-2-fluoropyridine. A mixture of 5-nitro-2-chloropyridine (2.0 g, 12.6 mmol) and anhydrous potassium fluoride (2.2 g, 38 mmol) in a combination of sulfalone ( 6 mL) and benzene (4 mL) was stirred at RT for 20 min. The benzene was then removed by distillation. The resulting mixture was heated at 150 ??C for 12h. The mixture was cooled to RT whereupon water (60 mL) was added. The desired product was separated from the solution via steam distillation. Extraction of the distillate with diethyl ether (2 ?á 1 0 mL) followed by drying (Na2SO4) and concentration gave the compound. 5-nitro-2-fluoropyridine, water white oil (1.3 g, 73%).
2-Fluoro-5-nitropyridine Preparation Products And Raw materials
Preparation ProductsN-Boc-5-amino-2-fluoropyridine-->5-AMINO-2-FLUORO-ISONICOTINIC ACID-->3-Amino-6-morpholinopyridine
2-FLUORO-3-NITROPYRIDINE 2-FLUORO-3-IODO-5-NITROPYRIDINE 2,3-DIFLUORO-5-NITROPYRIDINE Fluorine 5-FLUORO-3-NITROPYRIDINE-2-BORONIC ACID PINACOL ESTER 4-Fluoronitrobenzene 2-Chloro-3-cyanopyridine 2-Fluoro-4-methyl-5-nitropyridine 3-Bromo-2-fluoro-5-nitropyridine 2,6-Difluoro-3-nitropyridine Flupirtine TRITON 2,6-Lutidine Nitrobenzene 2-Fluoro-5-nitropyridine 2-FLUORO-5-NITRO-3-PICOLINE 2-FLUORO-5-NITRO-6-PICOLINE 1-Fluoro-2-nitrobenzene
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