ChemicalBook Product Catalog Organic Chemistry Hydrocarbons and derivatives Hydrocarbon halides 1-Bromo-2,3-difluorobenzene

1-Bromo-2,3-difluorobenzene

1-Bromo-2,3-difluorobenzene Basic information
Product Name:1-Bromo-2,3-difluorobenzene
Synonyms:2,3- twofluorine broMine;1-Bromo-2,3-difluorobenzene 98%;2,3-DIFLUOROBROMOBENZENE;1-BROMO-2,3-DIFLUOROBENZENE;2,3-DifluoroBrmorobenzene;1-Bromo-2,3-Difluorobenzenne;2,3-Difluorobromobenzene 98%;2,3-Difluorobromobenzene98%
CAS:38573-88-5
MF:C6H3BrF2
MW:192.99
EINECS:609-564-8
Product Categories:Miscellaneous;Aryl;Fluorobenzene Series;Fluorobenzene;C6;Halogenated Hydrocarbons;Other fluorin-contained compounds;Aromatic Halides (substituted);Purines;38573-88-5
Mol File:38573-88-5.mol
1-Bromo-2,3-difluorobenzene Structure
1-Bromo-2,3-difluorobenzene Chemical Properties
Boiling point 234 °C (765 mmHg)
density 1.724 g/mL at 25 °C(lit.)
refractive index n20/D 1.509(lit.)
Fp 142 °F
storage temp. 2-8°C
form clear liquid
Specific Gravity1.724
color Colorless to Almost colorless
InChIKeyRKWWASUTWAFKHA-UHFFFAOYSA-N
CAS DataBase Reference38573-88-5(CAS DataBase Reference)
Safety Information
Hazard Codes Xi,F
Risk Statements 36/37/38
Safety Statements 26-36/37/39-37/39
RIDADR 1993
WGK Germany 3
Hazard Note Flammable
HazardClass 3.2
PackingGroup III
HS Code 29039990
MSDS Information
ProviderLanguage
SigmaAldrich English
ACROS English
ALFA English
1-Bromo-2,3-difluorobenzene Usage And Synthesis
Chemical PropertiesClear colorless to peach liquid
Uses1-Bromo-2,3-difluorobenzene may be used in the synthesis of potent, orally active Calcitonin gene-related peptide (CGRP) receptor antagonist (BMS-846372). It may be used in the preparation of 2,3-difluorophenyl(dimethyl)phosphane.
Usesintermediate for liquid crystal and drugs
General DescriptionMicrobial oxidation of 1-bromo-2,3-difluorobenzene by Pseudomonas putida strain 39/D and Escherichia coli recombinant microorganism (strain JM 109(pDTG601)) has been reported.
SynthesisAdd 50% aqueous solution of KOH (18.0 g, 160 mmol) to a mixture of 1-bromo-5,5,6,6-tetrafluorocyclohex-1-ene (11.65 g) and triethylbenzylammonium chloride (0.15 g, 0.7 mmol) at 30-35°C for 30 minutes. Keep the reaction mixture at 75-85°C for 2 hours. Cool the reaction mixture. Dilute the reaction mixture with water. Extract the organic product with CH2Cl2. Dry the organic product over CaCl2. Distill the organic product. 1H NMR (CDCl3, 300.1 MHz), δ: 7.00-7.16 (m, 1H, Ar); 7.17-7.29 (m, 1H, Ar); 7.34-7.47 (m, 1H, Ar). 13C NMR (CDCl3, 75.5 MHz), δ: 110.40 (d, C(1), J = 17.5 Hz); 116.40 (d, C(4), J = 17.7 Hz); 124.70 (dd, C(5), J = 7.1 Hz, J = 5.0 Hz); 128.23 (d, C(6), J = 3.6 Hz); 148.10 (dd, C(2), J = 248.8 Hz, J = 14.3 Hz); 150.92 (dd, C(3), J = 251.9 Hz, J = 13.3 Hz). 19F NMR (CDCl3, 282.4 MHz), δ: -130.9 (m, 1 F, Ar), -134.8 (m, 1 F, Ar). BP 157-158°C. Elemental Analysis Found (%): C, 37.54; H, 1.50. C6H3BrF2. Calculated (%): C, 37.34; H, 1.52. Mass Spec MS, m/z (Irel (%)): 194, 192 [M]+ (100, 99), 113 [M-Br]+ (88), 63 (60).
synthetic method of 1-Bromo-2,3-difluorobenzeneFig The synthetic method of 1-Bromo-2,3-difluorobenzene
1-Bromo-2,3-difluorobenzene Preparation Products And Raw materials
Raw materials2,3-Difluorotoluene
Preparation Products3-Bromo-2-fluoro-phenol-->4-BROMO-2,3-DIFLUOROBENZOIC ACID-->1,4-DIBROMO-2,3-DIFLUOROBENZENE-->3-(4-Ethylphenyl)-1,2-difluorobenzene
4-BROMO-2,3,5,6-TETRAFLUOROANILINE 1-BROMO-2,3,6-TRIFLUOROBENZENE 1-Bromo-2,3,5-trifluorobenzene 3-BROMO-2,4,5,6-TETRAFLUORONITROBENZENE 4,4'-DIBROMOOCTAFLUOROBIPHENYL 2,3,4-Trifluorobromobenzene 1,3-DIBROMOTETRAFLUOROBENZENE Bromopentafluorobenzene 4-BROMO-2,3,5,6-TETRAFLUOROBENZONITRILE 1,2-Dibromotetrafluorobenzene 1-BROMO-2,3,4,5-TETRAFLUOROBENZENE 1,4-DIBROMOTETRAFLUOROBENZENE 1,2-DIBROMO-3,4,5-TRIFLUOROBENZENE 1-Bromo-2,3-difluorobenzene 4-BROMO-2,3,5,6-TETRAFLUOROBENZOIC ACID 1-BROMO-4-CHLORO-2,3,5,6-TETRAFLUOROBENZENE 2,4,5-TRIFLUORO-6-BROMOANILINE 1-bromo-2,3,4,6-tetrafluorobenzene
Email:[email protected] [email protected]
Copyright © 2024 Mywellwork.com All rights reserved.